Wnt信号通路在结直肠侧向发育型肿瘤中的研究进展

Advances in Research on Wnt Signaling Pathway in Colorectal Laterally Spreading Tumor

Wnt信号通路是一条进化上高度保守的信号通路,参与调控细胞的生长、分化、迁移、凋亡等生理过程,其异常激活与肿瘤发生密切相关。结直肠侧向发育型肿瘤(LST)是一种有着较高恶变潜能的肿瘤,Wnt信号通路的激活在LST的发生、发展中发挥重要作用。本文就Wnt信号通路在结直肠LST中的研究进展作一综述。

Wnt signaling pathway is an evolutionarily conserved system that participates in many physiological processes such as cell growth,differentiation,migration and apoptosis.Its abnormal activation is closely related to the occurrence of tumor.Colorectal laterally spreading tumor(LST)is a tumor with malignant potential.The activation of Wnt signaling pathway plays an important role in the occurrence of LST.This article reviewed the advances in research on Wnt signaling pathway in colorectal LST.