西替利嗪联合卡介菌多糖核酸治疗慢性荨麻疹的疗效探究

Efficacy of cetirizine combined with BCG polysaccharide nucleic acid in the treatment of chronic urticaria

目的探究西替利嗪联合卡介菌多糖核酸治疗慢性荨麻疹的疗效。方法研究对象为本院在2016年6月至2017年8月期间收治的慢性荨麻疹患者189例,依据随机偶数奇数法的分组方式分为对照组(n=94)与治疗组(n=95)两组,对照组单独予以西替利嗪进行治疗,治疗组在西替利嗪治疗基础上联合卡介菌多糖核酸进行治疗,观察并比较两组临床治疗效果、不良反应发生情况、临床症状积分及肿瘤坏死因子(TNF-α)、干扰素r(IFN-r)水平变化情况。结果在治疗总有效率比较上,治疗组显著高于对照组,两组间具有统计学意义(P<0.05);在不良反应发生率比较上,对照组与治疗组间差异无统计学意义;经过1个疗程治疗后,两组TNF-α水平低于治疗前,IFN-r高于治疗前,组间比较发现,治疗组优于对照组,差异有统计学意义(P<0.05);治疗前,两组瘙痒、风团数量、发作持续时间、总积分进行比较,差异无统计学意义;治疗1个疗程后比较,治疗组均少于对照组,组间差异有统计学意义(P<0.05)。结论慢性荨麻疹采用西替利嗪联合卡介菌多糖核酸治疗,效果良好,安全可行,可作为理想治疗方案在临床中进一步推广。

Objective To investigate the efficacy of cetirizine combined with BCG polysaccharide nucleic acid in the treatment of chronic urticaria.Methods189patients with chronic urticaria treated in our hospital from June2016to August2017were divided into two groups:control group(n=94)and treatment group(n=95).The control group was treated with cetirizine alone,and the treatment group was treated with BCG polysaccharide nucleic acid on the basis of cetirizine treatment.Clinical symptom score and tumor necrosis factor(TNF-α),the level of interferon r(IFNr)changed.Results The total effective rate in the treatment group was significantly higher than that in the control group(P<0.05),but there was no significant difference between the control group and the treatment group in the incidence of adverse reactions.After one course of treatment,the level of TNF-αin the two groups was lower than that before treatment and IFN-r was higher than that before treatment.The comparison between the two groups showed that the treatment group was superior to the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference between the two groups in pruritus,number of wind-induced sores,duration of attack and total score.After1course of treatment,the treatment group was less than the control group,and the difference between the groups was statistically significant(P<0.05).Conclusion The treatment of chronic urticaria with cetirizine combined with BCG polysaccharide nucleic acid has a good effect and is safe and feasible.It can be used as an ideal therapy in clinical practice.