观察血栓通注射液对伴有氯吡格雷抵抗(CR)脑梗死患者血小板聚集的影响

Effect of Xueshuantong injection on Platelet aggregation in patients with Cerebral Infarction with Clopidogrel Resistance

目的探讨对CR(氯吡格雷抵抗)脑梗死患者选择血栓通注射液加以治疗后对血小板聚集产生的影响。方法选择本院2016年7月至2018年1月收治的106例CR脑梗死患者作为实验对象;采用数字奇偶法分组;临床研究治疗药物期间,对照组(53例):选择常规西医+氯吡格雷药物加以疾病治疗;观察组(53例):选择常规西医+氯吡格雷+血栓通注射液加以疾病治疗;最终就两组CR脑梗死患者血小板聚集率变化加以对比。结果同对照组CR脑梗死患者血小板聚集率加以对比,观察组获得明显下降,差异有统计学意义(P<0.05);同对照组CR脑梗死患者NIHSS评分加以对比,观察组获得明显下降,差异有统计学意义(P<0.05);同对照组CR脑梗死患者用药总有效率(60.38%)对比,观察组(86.79%)获得明显提高,差异有统计学意义(P<0.05)。结论对于CR脑梗死患者临床选择血栓通注射液加以疾病治疗,于患者血小板聚集水平降低方面获得确切效果,从而促进CR脑梗死患者的病情好转以及恢复。

Objective To investigate the effect of XueshuanTong injection(XT)on platelet aggregation in patients with CR(clopidogrel resistance)cerebral infarction.Methods106patients with CR cerebral infarction admitted in our hospital from July2016to January2018were selected as experimental objects.Grouping by digital parity method;During the clinical research and treatment of drugs,the control group(53cases),conventional western medicine and clopidogrel drugs were selected for disease treatment;Observation group(53cases),conventional western medicine and clopidogrel and xueshuantong injection were selected for disease treatment;Finally,platelet aggregation rates of CR cerebral infarction patients in the two groups were compared.Results Compared with the control group,the platelet aggregation rate of the patients with CR cerebral infarction decreased significantly in the observation group(P<0.05),and the NIHSS score of the patients with CR cerebral infarction in the observation group was significantly decreased compared with the NIHSS score of the patients with CR cerebral infarction in the control group.The difference was statistically significant(P<0.05),compared with the total effective rate(60.38%)of the patients with CR cerebral infarction,the observation group(86.79%)obtained a significant increase,the difference was statistically significant(P<0.05).Conclusion Xueshuantong injection is used to treat CR patients with cerebral infarction.The reduction of platelet aggregation in patients with CR can promote the improvement and recovery of patients with cerebral infarction.