颗粒蛋白前体PGRN在生殖泌尿癌中的作用及展望

Progress and function of progranulin in genitourinary cancers

颗粒蛋白前体(progranulin,PGRN)是一种重要的生长因子,它与肿瘤的发生、演变过程有着密切的关系,是癌症中重要的转化调节因子.其在乳腺癌、肝癌等癌症的病变及恶化中扮演着重要的角色.此外,PGRN作为一种自分泌的生长因子,在几种生殖泌尿癌(包括卵巢癌、子宫内膜癌、宫颈癌、前列腺癌及膀胱癌)中可以通过促进肿瘤细胞增殖、调节转化细胞的运动和侵袭,从而影响相关癌症的发生和进展.也着重介绍了PGRN在这几种生殖泌尿癌中的相关作用,阐述PGRN在各种生殖泌尿癌中的相关研究,以期为泌尿生殖癌的靶向治疗提供新的思路.

Progranulin(PGRN),which is related to the occurrence and evolution of tumors closely,is an important growth factor and a regulator of transformation in cancers.In addition,it plays an important role in the progression and deterioration of cancers such as breast cancer and liver cancer.To date,in several genitourinary cancers(including ovarian,endometrial,cervical,prostate,and bladder tumors),PGRN acts as an autocrine growth factor,having an influence on progress of cancers through increasing the proliferation,regulating and transforming the motility and invasion of cancer cells.The article focus on the activity of PGRN in several genitourinary cancers,and expounds the research direction of PGRN in various genitourinary cancers,hoping to provide new ideas for the targeted therapy of genitourinary cancers.