甘露醇联合小剂量甲泼尼龙针在早期重症手足口病治疗中的应用效果分析

Analysis on application effect of mannitol combined with low-dose methylprednisolone needle in treatment of early severeHand-foot-mouth disease

目的观察分析甘露醇联合小剂量甲泼尼龙针在早期重症手足口病治疗中的应用效果。方法选取我院2014年5月～2017年5月200例早期重症手足口病患儿随机分成观察组与对照组,各100例,对照组给予常规对症支持治疗以及利巴韦林和喜炎平药物治疗,观察组在此基础上予甘露醇联合小剂量甲泼尼龙针治疗,观察记录两组患儿进展成危重症例数及主要症状体征消失时间,并进行对比分析。结果 (1)观察组进展为危重症例数显著少于对照组(P <0.05);(2)观察组发热、肢体抖动或惊跳等主要症状体征消失时间显著少于对照组,差异有统计学意义(P <0.05)。(3)观察组治疗总有效率显著优于对照组(P <0.05)。结论甘露醇联合小剂量甲泼尼龙针治疗早期重症手足口病患儿,能够有效地预防病情向危重症进展,有助于缓解病情、保护脑组织功能以及促进康复。

Objective To observe and analyze application effect of mannitol combined with low-dose methylprednisolone needle in treatment of early severe hand-foot-mouth disease.Methods200children with early severe hand-foot-mouth disease from May2014to May2017were randomly divided into the observation group and the control group,with100cases in each group.The control group wasgiven routine symptomatic support therapy and drug treatment with ribavirin and xiyanping.The observation group was treated by mannitol combined with low-dose methylprednisolone needle at basis of the control group.The number of children progressing to critical illness and disappearance time of main symptoms and signsin two groups were observed and recorded and they were compared and analyzed.Results(1)The number of children progressing to critical illness in the observation group was smaller than that of the control group(P<0.05).(2)Disappearance time of main symptoms and signs such as fever,limb shaking and startling in the observation group was significantly shorter than the control group.The differences were statistically significant(P<0.05).The total effective rate in the observation group was significantly higher than that in control group(P<0.05).Conclusion Mannitolcombined with low-dose methylprednisolone needle in treatment of early severe hand-foot-mouth disease can more effectively prevent the progression of disease to critical illness,help to alleviate the disease,protect brain tissue function and promote rehabilitation.