去甲肾上腺素与垂体后叶素在感染性休克治疗中的应用效果比较

Comparison of norepinephrine and pituitrin in the treatment of septic shock

目的比较去甲肾上腺素与垂体后叶素在感染性休克治疗中的应用效果。方法选择2014年1月～2017年11月我院收治的感染性休克患者78例,根据治疗方式的不同将入选患者分为A组(n=35)和B组(n=43)。A组患者采用去甲肾上腺素进行治疗;B组患者通过垂体后叶素进行治疗。观察比较两组患者6h内复苏成功率、治疗后血乳酸水平变化、多器官功能障碍综合征(MODS)发生率、机械通气支持时间及ICU住院时间的差异。结果 B组6h内复苏成功率比A组高,MODS发生率比A组低,差异有统计学意义(P <0.05);治疗后12、24、48h,B组患者血乳酸水平比A组低,差异有统计学意义(P <0.05);B组患者机械通气支持时间与ICU住院时间均比A组短,差异有统计学意义(P <0.05)。结论垂体后叶素治疗感染性休克的临床效果优于去甲肾上腺素,能有效减轻疾病损伤、改善组织缺氧、缩短患者机械通气支持时间与ICU住院时间,促进患者康复。

Objective To compare the effect of norepinephrine and pituitrin in the treatment of septic shock.Methods Seventy-eight patients with septic shock who treated in our hospital from January2014to November2017were selected and divided into group A(n=35)and group B(n=43)according to the different treatment methods.Patients in group A were treated by norepinephrine;and patients in group B were treated by pituitrin.The success rate of resuscitation within6h,the change of blood lactic acid level,the incidence of multiple organ dysfunction syndrome(MODS),the duration of mechanical ventilation support and ICU hospitalization time were observed and compared between the two groups after treatment.Results The success rate of recovery within6h in group B was higher than that in group A,and the incidence of MODS in group B was lower than that in group A,the difference was statistically significant(P<0.05).The blood lactate levels of patients in group B were lower than those in group A at12h,24h and48h after treatment(P<0.05).The support time of mechanical ventilation and ICU hospitalization time in group B were shorter than those in group A,the difference was significant(P<0.05).Conclusion The clinical effect of pituitrin in the treatment of septic shock is better than norepinephrine.It can effectively alleviate disease damage,improve tissue hypoxia,shorten the time of mechanical ventilation support and ICU hospitalization,and promote the rehabilitation of patients.