香豆素类近红外荧光染料应用研究进展

Progress on research and application of coumarin-based near-infrared fluorescence dyes

设计开发具有新型结构和功能的近红外荧光染料已成为目前研究的热点。香豆素类荧光染料具有优异的光物理和光化学性质,但由于其发射波长在短波区域,限制了其在活体成像中的应用。因此,设计开发近红外区域发射的香豆素类荧光染料具有非常重要的应用价值。本文根据结构类型进行分类,对近几年报道的香豆素类近红外荧光染料及其应用进行归纳总结,为设计开发更多新型香豆素类近红外荧光染料提供参考。

Design and development of near-infrared fluorescent dyes with novel structure and function have become a current research focus.Coumarins have been excellent candidate fluorophores in the design of fluorescent probes due to the outstanding photophysical and photochemical properties.However,these compounds mainly emit in the short-wavelength region,which limits their application in living samples.Therefore,it is essential to design and develop the coumarin fluorescent dyes that emit in the near-infrared region.In this review,the coumarin-based near-infrared fluorescence dyes which reported in recent years and their applications were summarized according to the structure types with the purpose of providing information for the future research and development.