银屑病早发型与晚发型临床差异的横断面调查

Cross-sectional investigation on clinical characteristics of early-onset and late-onset psoriasis

目的:调查早发型银屑病(发病年龄<40岁)与晚发型银屑病(发病年龄≥40岁)之间的临床差异。方法:对患者实行调查问卷研究,内容包括性别、年龄、发病年龄、身高、体重、家族史、既往史、加重因素、甲损害、舌改变、瘙痒情况、合并症等。结果:共纳入了352例银屑病患者,其中早发型279例,晚发型73例。5.73%早发型和15.07%晚发型患者中出现掌跖损害,差异有统计学意义(χ~2=7.170,P=0.007)。9.32%早发型和23.29%晚发型患者中出现合并症,差异有统计学意义(χ~2=10.528,P=0.001)。73.13%早发型患者和44. 83%晚发型患者在冬季复发加重,差异具有统计学意义(χ~2=12.207,P<0.01)。两组皮损PASI评分、SF-36量表总分、皮肤病生活质量评分(DLQI)方面,差异无统计学意义(P>0.05)。结论:早发型银屑病和晚发型银屑病存在临床差异。

Objective:To investigate the differences of clinical characteristics between early-onset psoriasis(age<40 years)and late-onset psoriasis(age≥40 years).Methods:All the patients with early and late-onset of psoriasis recruited in the study were asked to complete a questionnaires including gender,age,onset age,height,weight,family history,previous history,aggravating factors,nail damage,tongue changes,pruritus,complications.Results:The study included 352 psoriasis(279 early-onset and 73 late-onset).5.73%early-onset patients and 15.07%late-onset patients had palmoplantar lesions,with a significant difference(χ2=7.170,P=0.007).9.32%early-onset patients and 23.29%late-onset patients had complications,with a significant difference(χ2=10.528,P=0.001).73.13%early-onset patients and 44.83%late-onset patients relapsed in the wintert with a significant difference(χ2=12.207,P<0.01).There were no significant differences in PASI score,SF-36 score and DLQI score(P s>0.05)between the two groups.Conclusion:There are different clinical characteristics between early-onset psoriasis and late-onset psoriasis.