摘要
神经病理性疼痛(Neuropathic pain,NP)常伴有焦虑、抑郁和睡眠障碍等情况,严重影响患者身心健康。其发病机制复杂,缺乏有效的治疗手段。近年来,电压依赖性钙通道(Voltage-gated calcium channels,VGCC)已成为疼痛研究中的一大热点。第一个应用于临床治疗疼痛的多肽类钙通道阻滞剂ziconotide,已被美国FDA批准可经蛛网膜下腔给药用于慢性疼痛的治疗。本文介绍了VGCC的基本特点及其在镇痛治疗中的作用。
Neuropathic pain severely affects human health.and it is often accompanied by anxiety,depression,and sleep disorders.It remains poorly treated for large numbers of patients.In recent years,voltage-gated calcium channels have become a hot topic in pain research.The first polypeptide calcium channel blocker,ziconotide,which is used clinically to treat pain,has been approved by the US FDA for subarachnoid administration for chronic pain.We provide an overview of the basic characteristics of VGCC and its role in the treatment of analgesia.
作者
温爽
孙涛
WEN Shuang;SUN Tao(Department of Pain Management,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China)
出处
《实用药物与临床》
CAS
2018年第12期1327-1331,共5页
Practical Pharmacy and Clinical Remedies
基金
国家自然科学基金(81772443)
