黑曲发酵茯苓多糖免疫调节作用研究

Study on the Immunoregulation of Fermented Poria cocos Polysaccharides by Aspergillus niger

研究黑曲发酵茯苓多糖对免疫抑制小鼠的免疫调节作用,通过构建免疫抑制小鼠模型,将小鼠随机分为4组,即空白对照组(CK)、环磷酰胺模型组(cyclophosphamide,CY)及发酵茯苓多糖(fermented Poria cocos polysaccharides,FPCP)高、低剂量组。小鼠以灌胃方式给予不同剂量发酵茯苓多糖,分别测定脏器指数、血清溶血素水平、免疫球蛋白G(immunoglobulin G,IgG)与免疫球蛋白M(immunoglobulin M,IgM)含量及单核-巨噬细胞吞噬率。结果表明,与模型组相比,发酵茯苓多糖各剂量组均能显著提高小鼠脏器指数、溶血素水平、IgG与IgM含量、单核-巨噬细胞吞噬率。发酵茯苓多糖能有效增强环磷酰胺致免疫低下小鼠的免疫调节作用。

To study the immunoregulatory effect of Aspergillus niger fermentation polysaccharide on immunosuppressive mice,immunosuppressed mouse model was constructed.The mice were randomly divided into 4 groups:control check(CK),cyclophosphamide model group(CY),high-dose and low-dose groups of fermented Poria cocos polysaccharides(FPCP).The mice were given different doses of fermented polysaccharides by gavage,and the organ index,serum hemolysin level,immunoglobulin G(IgG)and immunoglobulin M(IgM)content,macrophage phagocytosis rate were measured.The results showed that compared with the model group(CY),each dose of FPCP significantly increased the mouse organ index,hemolysin level,IgG and IgM content,and macrophage phagocytosis rate.The polysaccharides fermented by Aspergillus niger can effectively enhance the immunoregulatory effect of immunocompromised mice.