阿奇霉素联合普米克令舒雾化吸入治疗小儿肺炎支原体感染的疗效及对免疫功能的影响

Effects of Azithromycin Combined with Pulmicort Respiratory Aspiration on Mycoplasma Pneumoniae Infection in Children and ts Effect on Immune Function

目的:研究探讨阿奇霉素联合普米克令舒雾化吸入治疗小儿肺炎支原体感染的疗效及对免疫功能的影响。方法:选取于我院确诊支原体肺炎的小儿90例并随机分为观察组及对照组,每组45例,观察组患儿采用阿奇霉素联合普米克令舒雾化吸入进行治疗,对照组患儿单用阿奇霉素治疗。观察并比较两组患儿各症状完全消失时间、血清免疫球蛋白(Ig)值变化情况、T淋巴细胞亚群变化情况、超敏C反应蛋白(hs-CRP)和细胞因子变化情况以及不良反应发生情况。结果:治疗后,观察组患儿发热、咳嗽、咳痰、胸闷、喘息以及肺部啰音等症状完全消失时间均明显低于对照组患儿(P<0.05)。两组患儿Ig值均有不同程度的升高,且观察组增幅明显大于对照组,其差异具有统计学意义(P<0.05)。治疗后,两组患儿CD3+、CD4+及CD4+/CD8+都有不同程度的升高,CD8+则出现下降,且观察组的增幅和降幅均明显大于对照组,其差异具有统计学意义(P<0.05)。两组患儿hs-CRP、白介素-6(IL-6)水平均出现下降,且观察组下降幅度明显大于对照组(P<0.05)。两组患儿均发生不同程度的恶心、呕吐、腹痛等不良反应,但观察组不良反应发生率显著低于对照组(P<0.05)。结论:相比单用阿奇霉素,采用阿奇霉素联合普米克令舒雾化吸入治疗小儿肺炎支原体感染疗,患儿症状更快缓解消失,更快改善患儿免疫功能,且无任何严重不良反应,值得在临床推广应用。

Objective:To study the effects of azithromycin combined with pulmicort respiratory aspiration on mycoplasma pneumoniae infection in children and its effect on immune function.Methods:90 children with mycoplasma pneumonia diagnosed in our hospital were randomly divided into observation group and control group,45 cases in each group.The observation group was treated with azithromycin and pulmicort Respiratory inhalation.The control group was treated with azithromycin alone.Observe and compared the time of complete disappearance of symptoms,changes in serum immunoglobulin(Ig)values,changes in T lymphocyte subsets,changes in hs-CRP and cytokines,and adverse events.occurrence in the two groups.Results:After treatment,the time of fever,cough,sputum,chest tightness,wheezing and lung tribal sounds disappeared in the observation group,which was significantly lower than that in the control group(P<0.05).The Ig values of the two groups were increased to varying degrees,and the increase in the observation group was significantly greater than that in the control group.The difference was statistically significant(P<0.05).After treatment,the levels of CD3+,CD4+,and CD4+/CD8+increased in different degrees in both groups,and CD8+decreased.The increase and decrease in the observation group were significantly greater than those in the control group,with a significant difference(P<0.05).The levels of hs-CRP and IL-6 in both groups were decreased,and the decrease in the observation group was significantly greater than that in the control group(P<0.05).Both groups had adverse reactions such as nausea,vomiting and abdominal pain,but the incidence of adverse reactions was significantly lower in the observation group than in the control group(P<0.05).Conclusion:Compared to azithromycin alone,the use of azithromycin combined with Pulmicort Respiratory Inhalation for the treatment of children with Mycoplasma pneumoniae infection can relieve the symptoms of children quickly disappear,and can improve the immune function of children with no serious adverse reactions.It is worth in clinical application.