支气管结核患者经纤支镜介入冷冻治疗的疗效分析

Clinical Analysis of Interventional Cryotherapy in Patients with Bronchial Tuberculosis by Fiberoptic Bronchoscopy

目的:分析探讨支气管结核患者经纤支镜介入冷冻治疗的疗效。方法:选取2016年10月至2017年10月期间收治的68例支气管结核患者,按照随机数字表法将所有患者简单随机分为对照组和试验组两组,两组患者均给予常规的抗结核化疗,而试验组患者则在此基础上联合使用纤支镜介入冷冻治疗,比较两组患者治疗后的痰菌转阴率和胸部CT变化情况以及纤支镜下变化情况。结果:治疗前对照组中痰菌阳性患者30例,痰菌阴性患者4例,试验组中痰菌阳性患者28例,痰菌阴性患者6例;经过治疗后对照组中痰菌阳性患者14例,痰菌阴性患者20例,试验组中痰菌阳性患者9例,痰菌阴性患者25例;经过治疗后试验组患者的痰菌转阴率为89.29%,显著高于对照组患者的66.67%(χ~2=8.934,P <0.05)。经过治疗后试验组患者的总有效率为91.18%,显著高于对照组患者的64.71%(χ~2=9.273,P <0.05)。经过治疗后试验组患者的纤支镜检查结果总有效率为94.12%,显著高于对照组患者的70.59%(χ~2=10.029,P <0.05)。结论:对支气管结核患者采用经纤支镜介入冷冻治疗联合全身化疗能够有效提高患者的痰菌转阴率,大大改善患者的临床疗效,值得在临床上加以推广运用。

Objective:To analyze the curative effect of interventional cryotherapy for bronchial tuberculosis patients by fiberoptic bronchoscope.Methods:Sixty-eight patients with bronchial tuberculosis admitted to our hospital from October 2016 to October 2017 were randomly divided into control group and experimental group.Both groups were given routine anti-tuberculosis chemotherapy,while the experimental group was given fiberoptic bronchoscopic interventional cryotherapy on this basis.The sputum negative rate,chest CT changes and changes under bronchoscope were compared between the two groups.Results:There were 30 sputum positive patients,4 sputum negative patients,28 sputum positive patients and 6 sputum negative patients in the control group before treatment.After treatment,there were 14 sputum-positive patients,20 sputum-negative patients,9 sputum-positive patients and 25 sputum-negative patients in the control group,respectively.After treatment,the sputum negative rate of the experimental group was 89.29%,which was significantly higher than that of the control group 66.67%(χ2=8.934,P<0.05).The total effective rate of the experimental group was 91.18%,which was significantly higher than that of the control group(χ2=9.273,P<0.05).The total effective rate of fiberoptic bronchoscopy in the experimental group was 94.12%,which was significantly higher than 70.59%in the control group(χ2=10.029,P<0.05).Conclusion:Transbronchoscopic cryotherapy combined with systemic chemotherapy can effectively improve the sputum negative rate of patients with bronchial tuberculosis,greatly improve the clinical efficacy of patients.It is worthy of clinical application.