血清胃蛋白酶原Ⅰ、Ⅱ在慢性萎缩性胃炎诊治中的临床应用

Clinical application value of serum pepsinogenⅠ,Ⅱin the diagnosis and treatment of chronic atrophic gastritis

目的 通过测定血清胃蛋白酶原Ⅰ(PGⅠ)、PGⅡ、PGⅠ与PGⅡ比值(PGR)在慢性萎缩性胃炎(AG)患者血清中的水平,评估以上指标在慢性萎缩性胃炎(AG)诊断中的价值。方法2016年1月至2017年12月在阳春市中医院采用胶乳增强免疫比浊法测定健康对照组(n=10)、慢性非萎缩性胃炎(NAG)组(n=52)、萎缩性胃炎(AG)组(n=52)受试人员血清中的PGⅠ、PGⅡ、PGR水平。评价以上指标在AG诊断中的价值。结果 AG组血清PGⅠ、PGR水平较健康对照组明显下降,差异均有统计学意义(P<0.05)。NAG组血清PGⅠ、PGR水平与健康对照组相比无明显变化,差异无统计学意义(P>0.05)。结论 PGⅠ、PGⅡ、PGR联合检测在慢性萎缩性胃炎中有较高的诊断价值。

Objective To measure the serum levels of pepsinogenⅠ(PGⅠ),PGⅡ,and PGⅠ/PGⅡratio(PGR)in patients with chronic atrophic gastritis(AG),evaluate the value of these indicators in the diagnosis of chronic atrophic gastritis(AG).Methods Latex enhanced immunoturbidimetric was used to determine serum PGⅠ,PGⅡ,PGR levels of healthy control group(n=10),chronic non-atrophic gastritis(NAG)group(n=52),atrophic gastritis(AG)group(n=52)in Yangchun Hospital of Traditional Chinese Medicine from January 2016 to December 2017,and the value of these indicators in the diagnosis of chronic atrophic gastritis(AG)were evaluated.Results Serum PGⅠ,PGR levels in AG group were significantly lower than those in healthy control group,with statistically significant differences(P<0.05).There were no statistically significant differences in serum PGⅠ,PGR levels between NAG group and healthy control group(P>0.05).Conclusion PGⅠ,PGⅡ,PGR joint detection has high diagnostic value in chronic atrophic gastritis.