血清CA19-9、CA15-3、CEA、NES联合检测对肺癌的诊断价值

Diagnostic Value of Combined Detection of Serum CA19-9,CA15-3,CEA and NES for Lung Cancer

目的探讨血清CA19-9、CA15-3、CEA、NES联合检测在临床诊断肺癌的应用价值。方法选取肺癌患者60例作为研究组。另选取同期健康体检者60例为对照组。采用化学发光免疫分析法分别检测研究组患者在术前、术后3个月的空腹血清CA19-9、CA15-3、CEA、NES水平,并与对照组各血清肿瘤标志物检测结果作对比,并比较肺癌不同病理分期血清CA19-9、CA15-3、CEA、NES水平情况,以及分析其联合检测对肺癌的临床诊断价值。结果研究组术后3个月血清CA19-9、CA15-3、CEA、NES水平均明显低于术前(P <0. 05);而其术后3个月血清肿瘤标志物与对照组相比差异均无统计学意义(P> 0. 05);研究组术前临床分期Ⅲ～Ⅳ期患者CA19-9、CA15-3、CEA、NES水平均明显高于临床分期Ⅰ～Ⅱ期患者水平(P <0. 05);检测血清CA19-9、CA15-3、CEA、NES早期诊断肺癌的敏感度分别为53. 33%(32/60)、68. 33%(41/60)、78. 33%(47/60)、75. 00%(45/60),特异性分别为88. 33%(53/60)、91. 67%(55/60)、86. 67%(52/60)、90. 00%(54/60)。而联合检测的敏感度及特异度分别为86. 67%(52/60)、93. 33%(56/60)。结论肺癌患者血清CA19-9、CA15-3、CEA、NES水平升高,联合检测可明显提高其诊断价值,可作为肺癌临床诊断指标。

Objective To investigate the clinical value of combined detection of serum CA19-9,CA15-3,CEA and NES in the diagnosis of lung cancer.Methods 60 patients with lung cancer treated in our hospital from March 2014 to March 2017 were selected as the study group.Another 60 cases in our hospital during the same period of physical examination as the control group.The levels of fasting serum CA19-9,CA15-3,CEA and NES were detected by chemiluminescence immunoassay in the study group before and after the operation in March.And with the control group the serum tumor marker test results for comparison,and comparison of lung cancer of different pathological stages of serum CA19-9,CA15-3,CEA,NES level,and analyze the clinical diagnostic value of the combined detection of lung cancer.Results The serum levels of CA19-9,CA15-3,CEA and NES in the study group were significantly higher than those before operation(P<0.05)3 months after operation;Compared with the control group,the tumor markers in the 3 months after operation were statistically significant(P>0.05);CA19-9,CA15-3,CEA and NES levels were significantly higher in the study group than those in the clinical stage(P<0.05);The serum levels of CA19-9,CA15-3,CEA and NES in the early diagnosis of lung cancer sensitivity was 53.33%(32/60),68.33%(41/60),78.33%(47/60),75%(45/60),the specificity was 88.33%(53/60),91.67%(55/60),86.67%(52/60),90%(54/60).The sensitivity and specificity of combined detection were 86.67%(52/60)and 93.33%(56/60),respectively.Conclusion The levels of serum CA19-9,CA15-3,CEA and NES in patients with lung cancer are increased.Combined detection can improve the diagnostic value of lung cancer,and can be used as a clinical indicator of lung cancer.