西咪替丁联合依巴斯汀治疗过敏性皮肤病的临床效果

Combination of ebastine and cimetidine for allergic skin disease

目的 探究依巴斯汀联合西咪替丁对过敏性皮肤病的临床治疗效果。方法 将160例过敏性皮肤病患者按照随机数字表法分成2组,每组80例。对照组口服依巴斯汀片10 mg治疗,1次/d;研究组在口服依巴斯汀片的基础上口服200 mg西咪替丁,1次/d;均连续治疗4周。比较两组治疗前后临床症状评分、治疗效果、不良反应情况,并持续随访1个月,观察两组复发情况。结果 治疗后,研究组症状评分显著低于对照组,差异有统计学意义(t=3.438,P=0.001)。两组疗效等级分布差异有统计学意义(Z=2.397,P=0.017),且研究组治疗总有效率显著高于对照组(χ2=4.440,P=0.035);两组不良反应率(χ2=0.360,P=0.548)及治疗完成后1个月内症状复发率(χ2=0.250,P=0.617)差异均无统计学意义。结论 西咪替丁联合依巴斯汀治疗过敏性皮肤病,疗效优于单一依巴斯汀治疗方案。

Objective To investigate the clinical effect of combination of ebastine and cimetidine for allergic skin diseases.Methods 160 patients with allergic skin disease were divided into a control group and a study group using random number table method,80 cases for each group.The control group orally took 10 mg ebastine,once a day;the study group orally took 10 mg ebastine and 200 mg cimetidine,once a day.Both groups were treated for 4 weeks.The clinical symptom score,treatment effects,and adverse reactions were compared between the two groups before and after the treatment.The patients were followed up for one month and the recurrences of the two groups were observed.Results After the treatment,the symptom score of the study group was significantly lower than that of the control group(t=3.438,P=0.001).There was a statistical difference in the distribution of curative effect between the two groups(Z=2.397,P=0.017);and the total effective rate of the study group was significantly higher than that of the control group(χ2=4.440,P=0.035).There were no statistical differences in the adverse reaction rate and the symptom recurrence rate within one month between the two groups(both P>0.05).Conclusion The combination of cimetidine and ebastine for allergic skin diseases is more effective than the single ebastine treatment.