低分子肝素治疗子痫前期合并胎儿生长受限对生长发育指标及对ho-1表达水平的影响

Effects of low molecular weight heparin on growth and development indicators and ho-1 expression level in pre-eclampsia patients with fetal growth restriction

目的 探究与分析低分子肝素治疗子痫前期合并胎儿生长受限的疗效及生长发育的影响。方法 选取本院2015年4月至2017年4月收治的子痫前期合并胎儿生长受限患者90例,采取随机数字表法分为两组,各45例,对照组给予硫酸镁治疗,观察组在对照组基础上加用低分子肝素治疗,对比两组治疗前后临床疗效、治疗前后1周彩超监测胎儿生长情况及脐血流指标、新生儿Apgar评分、体质量、胎盘质量及对HO-1表达水平的影响。结果 观察组临床总有效率91.11%高于对照组73.33%,差异有统计学意义(P<0.05);治疗前,两组患儿双顶径、股骨长度、腹围、头围、S/D比值、PT、RI比较,差异均无统计学意义(均P>0.05);对照组治疗前后双顶径、股骨长度、腹围、头围、S/D比值、PT、RI比较,差异均无统计学意义(均P>0.05);观察组双顶径、股骨长度、腹围、头围较治疗前升高,S/D比值、PT、RI较治疗前降低,差异均有统计学意义(均P<0.05);观察组新生儿Apgar评分、体质量、胎盘质量高于对照组,差异均有统计学意义(均P<0.05);观察组胎盘HO-1强阳性及中度阳性表达所占比例高于对照组,差异均有统计学意义(均P<0.05)。结论 在硫酸镁基础上低分子肝素治疗子痫前期合并胎儿生长受限的疗效显著,能够进一步促进生长发育。

Objective To explore and analyze the effect of low molecular heparin in the treatment of pre-eclampsia complicated with fetal growth restriction and the effects on growth and development.Methods 90 cases of pre-eclampsia complicated with fetal growth restriction treated at our hospital from April,2015 to April,2017 were selected,and randomly divided into a control group and an observation group,45 cases for each group.The control group were treated with magnesium sulfate;in addition,the observation group were treated with low molecular heparin.The clinical curative effect,fetal growth situation and umbilical cord blood flow indicators before and 1 week after the treatment,neonatal Apgar score,body weight,placenta quality,and ho-1expression level were compared between these two groups.Results The total clinical efficacy was higher in the observation group than in the control group(91.11%vs.73.33%),with a statistical difference(P<0.05).There were no statistical differences in biparietal diameter,femur length,abdomen circumference,head circumference,S/D ratio,PT,and RI between these two groups before the treatment,and no between before and after the treatment in the control group(P>0.05).The biparietal diameter,femur length,abdomen circumference,and head circumference were higher and the S/D ratio,PT,and RI were lower after than before the treatment in the observation group,with statistical differences(all P<0.05).The neonatal Apgar score,body weight,and placenta quality were higher in the observation group than in the control group,with statistical differences(all P<0.05).The proportions of strong and moderate positive expressions of HO-1 were higher in the observation group than in the control group,with statistical differences(both P<0.05).Conclusion Low molecular heparin combining magnesium sulfate is effective in the treatment of pre-eclampsia complicated with fetal growth restriction,and can further promote growth and development.