盐酸坦索罗辛联合呋塞米对输尿管结石患者行体外冲击波碎石术后排石效果及不良反应观察

Observation of Tamsulosin Hydrochloride Combined with Furosemide on Effectiveness of Removing Urinary Calculus and Adverse Reactions in Patients with Ureteral Calculi after Extracorporeal Shock Wave Lithotripsy

目的探究盐酸坦索罗辛联合呋塞米对输尿管结石患者行体外冲击波碎石术(ESWL)后排石效果及不良反应的影响。方法回顾性分析2016年2月—2017年12月行ESWL治疗的256例输尿管结石患者的临床资料。按治疗方法不同分为联合组和常规组,每组128例。常规组术后予以呋塞米治疗,联合组术后给予盐酸坦索罗辛联合呋塞米治疗。记录两组各段输尿管排石成功率及排石成功者的排石时间,观察两组的疼痛情况和不良反应发生情况,并比较两组治疗前后生活质量差异。结果联合组上段及下段输尿管排石成功率明显高于常规组(P <0. 05)。联合组各段输尿管排石成功者的排石时间、肾绞痛和膀胱刺激征发生率以及镇痛药使用率均低于常规组(P <0. 05)。治疗1个月后,两组生活质量综合评定问卷评分均高于治疗前,且联合组高于常规组(P <0. 01)。两组治疗期间不良反应总发生率比较差异无统计学意义(P> 0. 05)。结论盐酸坦索罗辛联合呋塞米对输尿管结石患者ESWL术后的排石效果显著,不仅能增加排石成功率、减少排石时间,还能缓解疼痛程度、提升生活质量,且不增加不良反应。

Objective To investigate effects of Tamsulosin Hydrochloride combined with Furosemide on effectiveness of removing urinary calculus and adverse reactions in patients with ureteral calculi after extracorporeal shock wave lithotripsy(ESWL).Methods Clinical data of 256 patients with ureteral calculi undergoing ESWL during February 2016 and December 2017 was retrospectively analyzed,and the patients were divided into combined group and routine group(n=128 for each group)according to different therapeutic methods.Routine group was treated with Furosemide after operation,while combined group was treated with Tamsulosin Hydrochloride combined with Furosemide after operation.In two groups,successful rates of removing urinary calculus in ureteral segments and times of successfully removing urinary calculus were recorded,and conditions of pain and adverse reactions were observed,and differences in quality of life before and after treatment were also compared.Results Successful rates of lithotripsy in superior and lower ureteral segments in combined group were significantly higher than those in routine group(P<0.05).Values of lithotripsy time,incidence rates of renal colic and irritation symptoms of bladder and use rate of analgesics in combined group were significantly lower than those in routine group(P<0.05).After treatment for one month,scores of generic quality of life inventory(GQOLI-74)were significantly higher than those before treatment in two groups,and the score in combined group was significantly higher than that in routine group(P<0.01).There was no significant difference in incidence rate of adverse reactions during treatment between two groups(P>0.05).Conclusion Tamsulosin Hydrochloride combined with Furosemide in treatment of ureteral calculi patients after ESWL may achieve good lithotripsy effectiveness,and it may not only increase successful rate of lithotripsy and reduce time of lithotripsy,but also relieve pain and improve quality of life without increasing incidence rate of adverse reactions.