清胃健中汤联合埃索美拉唑治疗消化性溃疡的疗效分析

Curative Effects of Qingwei Jianzhong Decoction Combined with Esomeprazole in the Treatment of Peptic Ulcer

目的:探讨清胃健中汤辅以埃索美拉唑治疗消化性溃疡的临床疗效分析及对胃肠激素、炎性因子和血流变学的影响。方法:选取2015年7月至2016年6月黑龙江省中医药科学院收治的消化性溃疡患者112例,按照随机数字表法随机分为观察组和对照组,每组56例。对照组采用埃索美拉唑治疗,观察组在对照组的基础上加用清胃健中汤,2组均连续用药1个月。评估2组患者临床疗效,比较2组治疗前后胃肠激素、炎性因子和血流变学指标的变化。结果:观察组总有效率为98. 21%,显著高于对照组的82. 14%(P <0. 05)。与治疗前比较,2组治疗后血清胃肠激素指标均有所改善,且观察组改善更为明显(P <0. 05或P <0. 01); 2组患者治疗后hs-CRP、IL-6和TNF-α等炎性因子水平,全血高切、中切、低切黏度,红细胞沉降率和红细胞比容水平均有不同程度的降低(P <0. 05或P <0. 01),且观察组较对照组降低的更为明显(P<0. 05或P <0. 01)。结论:清胃健中汤联合埃索美拉唑可有效治疗消化性溃疡,降低患者体内炎性反应因子水平,并能平衡机体胃肠激素和血流变学指标水平,效果显著。

Objective:To explore the clinical efficacy of Qingwei Jianzhong Decoction combined with esomeprazole in the treatment of peptic ulcer and its influnce on gastrointestinal hormones,inflammatory factor and hemorrheology.Methods:A total of 112 cases of patients with peptic ulcer in Heilongjiang Academy of Chinese Medicine from July 2015 to June 2016 were selected,and were randomly divided into treatment group(n=56)and control group(n=56).The control group was treated with esomeprazole,and the treatment group was added Qingwei Jianzhong Decoction on the basis of control group.Both groups were treated continuously for 1 month.The clinical efficacy in 2 groups was evaluated,and the changes of gastrointestinal hormones,inflammatory factor and hemorrheology in 2 groups were detected and compared.Results:The total effective rate of the treatment group was 98.21%,which was significantly higher than the 82.14%of the control group(P<0.05);Compared with data before treatment,the serum gastroenterin indexes of 2 groups were improved after treatment,and the improvement of treatment group was more obvious(P<0.05 or P<0.01);Compared with before treatment data,the levels of inflammatory factors,such as hs-CRP,IL-6 and TNF-α,the whole blood high,medium and low cutting viscosity,and the blood sedimentation and erythrocyte volume,were all decreased in different degrees(P<0.05 or P<0.01);The reduction of treatment group was more obvious than control group(P<0.05 or P<0.01).Conclusion:Qingwei Jianzhong Decoction combined with esomeprazole can effectively treat patients with peptic ulcer,reduce the level of inflammatory factors in patients,and strike a balance between the level of gastrointestinal hormones and hemorheology indicators,and its effect is remarkable.