基于血小板及其膜的仿生递药系统研究进展

Advances in biomimetic drug delivery systems based on platelet and platelet membrane

血小板是人体血液中重要的固有成分,在机体各类生理反应中发挥重要作用。近年来,基于血小板及其膜的仿生新型药物传递系统备受关注。与传统药物载体相比,血小板及其膜仿生递药系统具有生物相容性好、血液循环时间长和体内靶向性强等优势。本文介绍了基于血小板及其膜仿生递药系统的特点、种类、载药方式及应用,以期促进血小板及其膜仿生载体在药物递送领域的研究与应用。

Platelet is an important component of human blood,which plays a key role in the physiological and pathological processes.Recently,novel drug delivery system based on platelet and platelet membrane bionics attracted much attention.Compared to the traditional drug carriers,platelet and platelet membrane-based biomimetic drug delivery system has great performances in biocompatibility,longer circulation and stronger ability of targeting.This review presented the features,classifications,drug-loading and applications of platelet and platelet membrane-based biomimetic drug delivery systems,promoting their development and application in the future.