综合护理干预治疗非酒精性脂肪肝的临床观察

Clinical observation of comprehensive nursing intervention for nonalcoholic fatty liver disease

目的观察综合护理干预对非酒精性脂肪性肝病(NAFLD)患者的治疗效果。方法 60例NAFLD患者为研究对象,所有患者采用综合护理干预,干预时间为30 d。比较观察患者干预前后体质量指数(BMI)、肝脏功能、肝脏瞬时弹性成像(Fibroscan)肝细胞脂肪含量指标。结果干预后,患者BMI、丙氨酸转氨酶(ALT)、谷草转氨酶(AST)、总胆固醇(TC)、甘油三酯(TG)水平分别为(21.66±3.13)kg/m2、(25.16±4.81)U/L、(19.96±5.24)U/L、(4.27±0.89)mmol/L、(1.54±0.41)mmol/L,显著低于干预前的(31.38±4.61)kg/m2、(53.66±11.47)U/L、(44.39±9.82)U/L、(5.61±1.30)mmol/L、(2.58±0.61)mmol/L,差异具有统计学意义(P<0.05)。干预后,患者Fibroscan肝细胞脂肪含量(248.22±28.15)dB/m低于干预前的(266.47±32.48)dB/m,差异具有统计学意义(P<0.05)。结论综合护理干预治疗NAFLD效果显著,能够改善患者BMI、肝脏功能、肝细胞脂肪含量指数,值得临床广泛应用。

Objective To observe the intervention effect of comprehensive nursing intervention for patients with nonalcoholic fatty liver disease(NAFLD).Methods A total of 60 NAFLD patients as study subjects all received comprehensive nursing for nursing intervention,with nursing time as 30 d.Comparison and observation were made on body mass index(BMI),liver function,and liver transient radiography(Fibroscan)hepatocyte fat content index before and after intervention of all patients.Results After intervention,patients had significantly lower BMI,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total cholesterol(TC),and triglyceride(TG)levels respectively as(21.66±3.13)kg/m^2,(25.16±4.81)U/L,(19.96±5.24)U/L,(4.27±0.89)mmol/L and(1.54±0.41)mmol/L than(31.38±4.61)kg/m^2,(53.66±11.47)U/L,(44.39±9.82)U/L,(5.61±1.30)mmol/L and(2.58±0.61)mmol/L before treatment,and the differences were statistically significant(P<0.05).After intervention,patients had lower Fibroscan hepatocyte fat content as(248.22±28.15)dB/m than(266.47±32.48)dB/m before intervention,and the difference was statistically significant(P<0.05).Conclusion Comprehensive nursing intervention shows remarkable effect in the treatment of NAFLD,and it can improve BMI,liver function and hepatocyte fat content index of patients,it is worthy of clinical application widely.