长春地辛与长春新碱治疗儿童初发急性淋巴细胞白血病效果比较

Comparison of the effect of Changchun Di Xin and vincristine in the treatment of childhood acute lymphoblastic leukemia

目的分析长春地辛与长春新碱治疗儿童初发急性淋巴细胞白血病(ALL)的临床疗效。方法根据治疗方式的不同,将116例初发ALL患儿分为两组各58例,在化疗诱导期、强化期,A组患儿应用长春地辛,B组患儿应用长春新碱,观察比较两组患儿的短期疗效、不良反应情况。结果在诱导缓解期第15、33天,两组患儿的骨髓像分期比较,差异均无统计学意义(P>0.05)。A组患儿的完全缓解率为96.4%,B组为94.7%,两组患儿的完全缓解率比较差异无统计学意义(P>0.05)。A组患儿出现贫血、PLT减少、神经系统毒性不良反应发生率均显著低于B组,差异有统计学意义(P<0.05)。结论在儿童初发ALL的临床治疗中,长春地辛与长春新碱的短期疗效接近,但长春地辛的不良反应更少,安全性更好。

Objective The clinical efficacy of Changchun digoxin and vincristine in the treatment of childhood acute lymphoblastic leukemia(ALL)was retrospectively analyzed.Methods According to the different methods of treatment,the clinical data of116children with primary ALL were divided into two groups(n=58).In the chemotherapy induction period and the intensifying stage,the children of group A were used in Changchun digoxin,and the children in group B were treated with vincristine.The short-term efficacy and adverse reactions of the two groups were observed.Results At the15th and33d of the induction remission period,there was no significant difference in the bone marrow image staging between group A and group B(P>0.05).The complete remission rate was96.4%in group A and94.7%in group B.There was no significant difference in the complete remission rate between the two groups(P>0.05).The incidence of anemia,reduced PLT,and adverse neurological toxicity in group A were significantly lower than those in group B(P<0.05).Conclusion In the clinical treatment of children's initial ALL,the short-term curative effect of Changchun digoxin and vincristine is similar,but the adverse reactions of Changchun are less and the safety is better.