经颅超声辅助溶栓技术在缺血性脑卒中动物模型的应用

Application of transcranial ultrasound-assisted thrombolysis in animal models of ischemic stroke

经颅超声辅助溶栓,简称"超声溶栓",是一种使用超声技术辅助治疗缺血性脑卒中的方法,可以促进血栓的溶解,加快堵塞血管的再通,提高溶栓成功率,并且不增加症状性颅内出血等并发症的发生率。该溶栓技术进入临床试验已有十余年,但尚未得到普遍的认可。一个重要的原因是对该方法的安全性和有效性缺乏系统、严谨的研究和评估。本文总结了近十多年来国内外使用缺血性脑卒中动物模型进行超声溶栓的研究,并探讨了目前超声溶栓研究存在的一些问题及解决思路。

Transcranial ultrasound-assisted thrombolysis,also called sonothrombolysis(STL),is a method of treatment using ultrasound to promote clot dissolution and accelerate recanalization of occluded vessels in the brain with ischemic stroke.It has been demonstrated that STL can enhance the rate of thrombolysis without increasing complications such as symptomatic intracranial hemorrhage.Sonothrombolysis has been used in clinical trials for more than a decade,but has yet to be widely accepted.One of the main reasons is the lack of systematic and rigorous assessment of the safety and effectiveness of this approach.In this review,we summarize STL studies performed in animal models of ischemic stroke reported during the last10years and highlight some current issues and potential solutions.