猪肺磷脂注射液联合鼻塞式气道正压通气治疗新生儿呼吸窘迫综合征的效果

Effect of Poractant Alfa Injection combined with nasal positive airway pressure ventilation in the treatment of neonatal respiratory distress syndrome

目的探讨猪肺磷脂注射液联合鼻塞式气道正压通气(NCPAP)治疗新生儿呼吸窘迫综合征(NRDS)的效果。方法分析我院2016年5月～2018年4月收治的NRDS 140例临床资料,依据治疗方式不同分为对照组和观察组,每组各70例。对照组给于NCPAP治疗,观察组在对照组的基础上给予猪肺磷脂注射液治疗,观察两组治疗前后血气分析结果情况,观察两组的临床治疗效果。结果两组治疗前氧分压(PaO_2)、二氧化碳分压(PaCO_2)比较,差异均无统计学意义(P>0.05),治疗后两组PaO_2均高于治疗前,PaCO_2均低于治疗前,观察组治疗后PaO_2高于对照组,PaCO_2低于对照组,差异均有统计学意义(P<0.05)。观察组的临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论猪肺磷脂注射液联合NCPAP治疗NRDS,血气分析结果改善明显,效果良好。

Objective To investigate the effect of Poractant Alfa Injection combined with nasal positive airway pressure ventilation(NCPAP)in the treatment of neonatal respiratory distress syndrome(NRDS).Methods The clinical data of 140 cases of NRDS admitted to our hospital from May 2016 to April 2018 were analyzed.According to different treatment methods,they were divided into control group and observation group,70 cases in each group.The control group was with NCPAP,the observation group was treated with porcine lung phospholipids Injection on the basis of the control group.The blood gas analysis and clinical effect of the two groups before and after treatment were observed.Results There were no significant differences in PaO2 and PaCO2 before treatment between the two groups(P>0.05).After treatment,PaO2 of two groups was higher and PaCO2 was both lower than before treatment,PaO2 after treatment in the observation group was higher and PaCO2 was lower than those of the control group,the differences were statistically significant(P<0.05).The total effectiveness rate of clinical treatment in the observation group was higher than that in the control group,with statistical significance(P<0.05).Conclusion Poractant Alfa Injection combined with NCPAP for NRDS improves the blood gas analysis and obtain a favorable effect.