摘要
目前,颅内动脉瘤、脑血管狭窄等脑血管疾病已经成为威胁人类健康的隐患之一。血管粥样硬化是一系列脑血管疾病的发病基础。近年来,越来越多的研究证实,Wnt信号通路广泛参与脑血管粥样硬化的发生。因此,本文对Wnt信号通路在血管内皮细胞、巨噬细胞和平滑肌细胞功能障碍中的作用进行总结,以探讨Wnt信号通路在脑血管粥样硬化发生发展中的作用机制,为脑血管疾病的研究提供新方向。
The cerebrovascular diseases,such as intracranial aneurysms and cerebrovascular stenosis,have become a major threat to human health.Pathological studies of cerebrovascular diseases have identified that vascular atherosclerosis is the basis of a series of cerebrovascular diseases.Recently,more and more studies have confirmed that Wnt signaling pathway is widely involved in the pathogenesis of cerebrovascular atherosclerosis.This review summarizes the research of Wnt signaling pathway in the dysfunction of vascular endothelial cells,macrophages,and smooth muscle cells,and explore the role of Wnt signaling in cerebrovascular atherosclerosis,hoping to provide a new direction for the future research of cerebrovascular diseases.
作者
唐海双
黄清海
刘建民
TANG Hai-shuang;HUANG Qing-hai;LIU Jian-min(Department of Neurosurgery, Changhai Hospital, Navy Military Medical University, Cerebral Vascular Disease Research Center, Shanghai 200433)
出处
《中国临床医学》
2018年第6期988-991,共4页
Chinese Journal of Clinical Medicine
基金
国家重点研发计划资助(2016YFC1300700)
国家自然基金面上项目(81771264)~~