摘要
微小RNA(microRNA,miRNA)是一类内源性的非编码RNA,由于其能调节细胞代谢、增殖、凋亡、迁移等基本过程,因此在哺乳动物细胞的发育、分化和细胞内稳态中起着重要作用。它们的表达异常会导致各种病理过程发生。由于单个microRNA能够靶向大量的mRNA序列,因此miRNA异常表达能够影响转录并激活癌症相关通路。miR-23a是miRNA家族中的一员,研究表明miR-23a在肺癌形成和发展中发挥重要作用,本文就miR-23a在肺癌发生发展中的作用进行综述。
MicroRNAs are endogenous non-coding RNAs.MicroRNAs play an important role in the development,differentiation and homeostasis of mammalian cells due to their ability to regulate basic processes such as cell metabolism,proliferation,apoptosis and migration;Their abnormal expression can lead to a variety of pathological processes.Since a single microRNA can target a large number of mRNA sequences,aberrant miRNA expression can affect transcription and activate cancer-associated pathways.miR-23a is a member of the miRNA family.Studies have shown that miR-23a plays an important role in the formation and development of lung cancer.This article reviews the role of miR-23a in the development of lung cancer.
作者
孟祥磊
赖青云
罗耀玲
李杰
MENG Xiang-lei;LAI Qing-yun;LUO Yao-ling;LI Jie(Gannan Medical University,Grade 2016,Ganzhou,Jiangxi341000;Gannan Medical University,Department of Clinical Research Center,the First Affiliated Hospital,Ganzhou,Jiangxi341000;Gannan Medical University,Respiratory Department,the First Affiliated Hospital,Ganzhou,Jiangxi341000)
出处
《赣南医学院学报》
2018年第11期1165-1168,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
肺癌
miR-23a
侵袭
转移
耐药
预后
Lung cancer
miR-23a
Invasion
Metastasis
Drug resistance
Prognosis
