氯沙坦钾片与胺碘酮对风湿性心脏病患者心功能影响

Efficacy analysis of losartan potassium tablets combined with amiodarone in improving cardiac function in patients with rheumatic heart disease

目的探讨氯沙坦钾片与胺碘酮对风湿性心脏病患者心功能的影响。方法选取青海省交通医院自2016年1月至2018年3月收治的100例风湿性心脏病患者为研究对象,按随机数字表法将患者分为A、B两组,每组各50例。A组患者接受地黄类和利尿剂治疗,B组患者在A组基础上接受氯沙坦钾片与胺碘酮治疗。随访12个月,比较两组患者临床治疗有效率、超声心动图相关指标。结果治疗后12个月,A组有效率为74. 0%(37/50),低于B组的100. 0%(50/50),两组比较,差异有统计学意义(P <0. 05)。治疗后6、12个月,B组患者左室舒张末径、左室收缩末径均低于治疗前,且B组低于A组,差异均有统计学意义(P <0. 05)。治疗后6、12个月,两组患者的6 min步行距离、左室射血分数均高于治疗前,且B组高于A组,差异均有统计学意义(P <0. 05)。结论氯沙坦钾片与胺碘酮治疗风湿性心脏病临床效果显著,可降低左室舒张和收缩末径,提高6 min步行距离和左室射血分数,改善预后。

Objective To investigate the effect of losartan potassium tablets combined with amiodarone on cardiac function in patients with rheumatic heart disease.Methods A retrospective study was performed on 100 cases of patients with rheumatic heart disease who were admitted from January 2016 to March 2018.Patients were randomly divided into the Group A and Group B,with 50 cases in each group.Patients in Group A received rehmannia and diuretics,while patients in Group B received losartan potassium tablets and amiodarone on the basis of Group A.Patients in the two groups were followed up for 12 months to compare the clinical treatment efficiency and echocardiographic indicators.Results Twelve months after treatment,the number of invalid,effective and significant cases in Group A was 13,20 and 17,respectively,with an effective rate of 74.0%(37/50).The number of invalid,effective and significant cases in Group B was 0,25 and 25,respectively,and the effective rate was 100.0%(50/50),and the difference between the two groups was statistically significant(P<0.05).The left ventricular diastolic diameter and left ventricular systolic diameter of patients in Group B 6 and 12 months after treatment were lower than those before treatment,and lower than those in Group A,(P<0.05).The walking distance and left ventricular ejection fraction at 6 minutes and 12 months after treatment in both groups were higher than those before treatment,and those in Group B were higher than those in Group A,(P<0.05).Conclusion Losartan potassium tablets combined with amiodarone is effective in the treatment of rheumatic heart disease.It can not only reduce left ventricular diastolic and end-systolic diameter,but also increase 6min walking distance and left ventricular ejection fraction.