血清肿瘤标志物联合凝血四项诊断乙肝相关肝癌的价值

The value of tumor markers combined with coagulation four in the diagnosis of hepatitis B related liver cancer

目的:探讨肿瘤标志物联合凝血四项诊断乙肝相关肝癌的价值,为临床相关诊断提供参考。方法:选取我院于2015年11月至2017年11月期间收治的158例乙肝相关肝癌患者作为试验组,并选取同期收治的120例乙肝相关良性肝病患者作为对照组。对比两组受试者的凝血四项指标变化、肿瘤标志物水平变化及各自阳性率。结果:试验组甲胎蛋白(AFP)、血管内皮生长因子(VEGF)、α-L-岩藻糖苷酶(AFU)含量均高于对照组,差异均有统计学意义(P <0. 05);且试验组AFP、VEGF、AFU阳性率均高于对照组,差异有统计学意义(P <0. 05)。试验组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)均长于对照组,而纤维蛋白原(FIB)含量低于对照组,差异均有统计学意义(P <0. 05);且试验组PT、APTT、TT、FIB阳性率均高于对照组,差异均有统计学意义(P <0. 05)。结论:肿瘤标志物联合凝血四项诊断乙肝相关肝癌,具有诊断简便准确、阳性率高等特点,值得在临床相关诊断中推广。

Objective:To study the value of tumor markers combined with coagulation four in the diagnosis of hepatitis B related liver cancer,so as to provide reference for clinical diagnosis.Methods:158 patients with hepatitis B related liver cancer admitted to our hospital from November 2015 to November 2017 were selected as the experiment group,and 120 patients with benign liver disease were selected as the control group.Two groups of coagulation four items were detected.The changes of four indexes of blood coagulation,tumor markers and their respective positive rates were compared between the two groups.Results:The experiment group AFP,VEGF and AFU level were higher than the control group,the differences were statistically significant(P<0.05).The experiment group AFP,VEGF,AFU positive rate were higher than the control group,the difference were statistically significant(P<0.05).The experiment group PT,APTT and TT were higher than the control group,and the content of FIB was lower than the control group,the differences were statistically significant(P<0.05).In the experiment group,PT,APTT,TT,FIB positive rate were higher than the control group,the differences were statistically significant(P<0.05).Conclusion:Tumor markers combined coagulation four in the diagnosis of HBV related HCC,has simple and accurate characteristics of higher positive rate,worthy of promotion in clinical diagnosis.