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SNARE蛋白复合物在神经疾病与精神病中的作用研究进展 被引量:2

Role of SNARE Protein Complex in Neurological and Psychiatric Disorders
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摘要 突触传递是神经系统发挥功能的基础,由囊泡介导的物质转运是突触传递的基础。突触传递功能异常是神经与精神疾病的主要发病机制之一,可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体(SNARE)介导的突触囊泡的着位在神经递质释放中发挥关键作用,其异常将导致神经系统功能紊乱。因此,SNARE蛋白复合物与多种神经和精神疾病如癫痫、帕金森病、阿尔茨海默病、精神分裂症、抑郁症等的发生密切相关。阐明SNARE蛋白复合物在神经与精神疾病发病中的具体机制和作用,对神经与精神疾病的防治与药物开发有重要意义。 Synaptic transmission is the basis for the functioning of nervous system,while vesicle-mediated substance transport is the basis of synaptic transmission.Dysfunction of synaptic transmission is one of the major pathogenesis of neurological and psychiatric disorders.Soluble N-ethylmaleimide-sensitive factor attachment protein receptor(SNARE)mediated docking of synaptic vesicles plays a key role in neurotransmitters release,and its abnormality will lead to disorders of nervous system function.Therefore,SNARE protein complex is closely related to the occurrence of various neurological and psychiatric diseases,including epilepsy,Parkinson′s disease,Alzheimer′s disease,schizophrenia,depression and so on.It is of great significance for the prevention and treatment of neurological and psychiatric diseases and the development of drugs to elucidate the specific mechanism and role of SNARE protein complex in the pathogenesis of these diseases.
作者 黄冲 吴菁华 杜琪琪 梁淑华 蔡子聪 陶黎阳 张绘宇 HUANG Chong;WU Jinghua;DU Qiqi;LIANG Shuhua;CAI Zicong;TAO Liyang;ZHANG Huiyu(The Third Clinical College,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China;Department of Pathology ,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China)
出处 《医学综述》 2018年第23期4620-4624,4629,共6页 Medical Recapitulate
基金 广东省中医药局科研基金(20151274) 广州医科大学第三临床学院大学生科研项目 广州医科大学大学生科技创新项目(2017A034) 国家级大学生创新创业训练计划项目(201810570011)
关键词 神经疾病 精神病 可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体复合物 Neurological disorders Psychiatric disorders Soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex
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