维生素D与脓毒症关系的研究进展

Research Progress in Relationship between Vitamin D and Sepsis

维生素D在调节钙、磷代谢及维持骨骼生长发育等方面发挥着重要的生物学作用。维生素D通过抗感染、调节机体炎症反应以及调控免疫等在脓毒症的发生、发展中发挥作用。脓毒症患者普遍存在维生素D缺乏,而维生素D缺乏不仅会增加发生严重感染的概率,还增加患者的病死率。给予维生素D缺乏的脓毒症患者补充维生素D治疗,可改善患者的预后,降低病死率。但也有学者持不同意见,认为维生素D不能改善预后。基于此,为明确维生素D的具体作用还需要深入研究。

Vitamin D plays an important biological role in regulating calcium and phosphorus metabolism and maintaining bone growth and development.It also plays a role in the occurrence and development of sepsis by anti-infection,regulation of the body′s inflammatory response,and immune regulation.Vitamin D deficiency,which is common in sepsis patients,not only increases the chance of serious infections,but also increases the mortality.Vitamin D supplementation for patients with vitamin D-deficient sepsis can improve the prognosis and reduce the mortality.However,some scholars hold different opinions that vitamin D does not improve the prognosis.In order to clarify the specific role of vitamin D,further research is needed.