粪菌移植方法学现状

Current Methodology of Fecal Microbiota Transplantation

粪菌移植是通过重构患者肠道菌群的手段治疗疾病,已成功应用于复发性难辨梭状芽孢杆菌感染的治疗。近年来,粪菌移植的临床价值日益得到国内外医学界关注和认可,成为研究热点。粪菌移植方法学包括供体的选择、粪菌液的制备、移植途径、适应证等在应用中不断被更新,其理论体系亦从粪菌移植转变为菌群移植,展现出广阔的研究前景。然而,目前我国绝大多数医务人员对粪菌移植治疗疾病认识不足,仅数家医院开展了为数不多的病例研究。

robiota of patients,and has been successfully applied to recurrent Clostridium difficile infection.In recent years,the clinical value of fecal microbiota transplantation has gained increasing attention and recognition in the medical field at home and abroad,and has become a research hotspot.The methodology of fecal microbiota transplantation,including the selection of donors,the preparation of fecal fluid,the route of transplantation,indications,etc.,are constantly being updated in the application.The theoretical system has also changed from fecal microbiota transplantation to microbiota transplantation,and has displayed a wide research prospect.However,at present,most medical personnel in China are lack of understanding of the treatment of fecal microbiota transplantation,and only few hospitals have carried out a small number of case studies.