高血压发病机制及相关进展

Pathogenesis and Related Progress of Hypertension

高血压是脑卒中及冠心病发病的首要危险因素,是全球导致死亡的最重要因素之一,发病机制仍不明确。近年来,国内外学者对高血压发生发展的调控机制开展了深入研究,有多种可能发生发展机制,包括巨噬细胞极化、基因调控、肾素-血管紧张素-醛固酮系统和交感神经系统激活、中枢神经系统功能失调、肾脏损伤等。高血压发病机制的研究有助于制订合理的治疗措施,控制患者的血压水平,降低心脑血管事件发生率。

Hypertension is the leading risk factor for stroke and coronary heart disease and one of the most important factors leading to death worldwide.The pathogenesis is still unclear.In recent years,domestic and foreign scholars carry out in-depth research on the regulation mechanism of the occurrence and development of hypertension.There are many possible mechanisms for the development of hypertension,including macrophage polarization,gene regulation,and renin-angiotensin-aldosterone system and sympathetic nervous system activation,central nervous system dysfunction,and kidney damage etc.Research on the pathogenesis of hypertension helps to develop reasonable treatments to control blood pressure levels,and reduce the incidence of cardiovascular and cerebrovascular events.