代谢综合征危险因素及防治进展

Progress in Risk Factors of Metabolic Syndrome and Its Prevention and Treatment

代谢综合征(MS)自提出以来备受学者关注,其终点事件发生率高,特别是心脑血管事件已位居死亡三大原因之首,严重威胁人类健康。MS的发生发展受多种危险因素的影响,主要包括年龄、行为方式、遗传、昼夜节律、维生素D水平、肠道菌群稳态等,多种因素相互影响给MS的治疗带来很大困难。未来,对危险因素的深入研究不仅可以更全面阐释其形成机制,还可以加快相关靶点的药物研发进程,对MS的防治意义重大。

Metabolic syndrome(MS)has aroused great interest among scholars since its emergence,and its high incidence of end-point events especially cardiovascular events,has become the first cause of human death among the top three.The occurrence and development of MS are influenced by many kinds of risk factors,including age,behavior pattern,gene-tics,circadian rhythm,vitamin D level,intestinal flora homeostasis etc.The interactions of these factors bring great difficulties to the treatment.In the future,in-depth study of risk factors can not only explain the formation mechanism of MS more comprehensively,but also accelerate the process of drug research and development of the related targets,which is of great significance to the prevention and treatment of MS.