原发性肝癌患者术前CEA和CA153与临床病理特征和预后的关系

Relationship between Preoperative CEA and CA153 and Clinicopathologic Features and Prognosis of Patients with Hepatocellular Carcinoma

目的探讨原发性肝癌(HCC)患者术前癌胚抗原(CEA)及糖类抗原153(CA153)与临床病理特征及预后的关系。方法回顾性分析2008年12月至2017年1月就诊于首都医科大学附属北京地坛医院且于本院死亡的132例HCC患者的临床资料,分析术前CEA及CA153与临床病理特征及预后的关系。结果术前CEA水平升高与发生肿瘤个数显著相关(P <0. 05);术前CEA正常组中位总生存期(OS)为20个月,术前CEA异常组中位OS为10个月,生存分析结果显示术前CEA正常组患者中位OS较CEA异常组显著延长(P=0. 030)。Cox多元回归分析显示,甲胎蛋白水平、门静脉癌栓、BCLC分期、CEA水平及肿瘤大小是影响HCC预后的危险因素(P <0. 05)。结论术前CEA异常患者总生存时间更短,CEA水平对HCC患者的预后判断具有重要提示作用。

Objective To investigate the relationship of carcinoembryonic antigen(CEA),carbohydrate antigen153(CA153)with clinicopathological characteristics and prognosis in patients with hepatocellular carcinoma(HCC).Methods A total of132patients with hepatocellular carcinoma admitted to and died in Beijing Ditan Hospital,Capital Medical University between Dec.2008and Jan.2017were included in the study.The relationship of CEA and CA153with the clinicopathological features and prognosis were analyzed.Results Preoperative elevated CEA levels were significantly associated with tumor number(P<0.05).Median overall survival time was20months in the group with normal preoperative CEA,and10months in the group with abnormal preoperative CEA,and survival analysis showed that the difference was significant between the two groups(P=0.030).In the multivariate Cox regression analysis,alpha fetal protein level,portal vein cancer bolt,BCLC stage,CEA level and tumor volume were the prognostic factors of HCC.In the multivariate Cox regression analysis,AFP level,portal vein cancer bolt,BCLC stage,CEA level and tumor volume were the prognostic factors(P<0.05).Conclusion The patients with abnormal preoperative CEA have shorter overall survival time.CEA level plays an important role in predicting the prognosis of HCC patients.