核转录因子NF-κB、A20蛋白与多种皮肤病相关性研究进展

Research progress of association of transcription factor NF-κB and A20 protein with multiple skin deseases

皮肤是人体免疫系统的第一道屏障,皮肤病的发生、转归与免疫调节密不可分,随着对皮肤病发病机制的研究,越来越多的皮肤疾病与其易感因素得到了揭示,核转录因子NF-κB信号传导通路与锌指蛋白A20就是近年来研究的热点之一。NF-κB信号传导通路贯穿于机体多种生理、病理过程,如免疫反应的调节、炎症反应和肿瘤的转归等,它是信号从细胞表面转导到细胞内部的重要传递者,参与细胞生长、发育、凋亡等多种生理功能,A20通过负性调节NF-κB信号途径介导的细胞凋亡,研究两者与皮肤疾病的关系,对于探索皮肤疾病病因,为将来针对多种皮肤病寻找可能作用的靶点、研发基因治疗方案具有重要意义。本文通过总结近年来对NF-κB信号转导通路、A20的研究进展,综述两者与数种皮肤病关系。

Skin is the first barrier of human immune system.The occurrence and prognosis of some skin diseases are closely related to immune regulation.With the study of the pathogenesis of skin diseases,more and more skin diseases and their susceptibility factors have been revealed.Nuclear transcription factor NF-kappa B signal transduction pathway and zinc finger protein A20 are one of the hotspots in recent years.NF-kappa B runs through a variety of physiological and pathological processes,such as the regulation of immune response,inflammation and tumor recurrence.It is an important transmitter of signal transduction from cell surface to cell interior.It participates in many physiological functions such as cell growth,development and apoptosis.A20 negatively regulates apoptosis through NF-kappa B signaling pathway,and to study the relationship between them and skin diseases are of great significance for exploring the etiology of skin diseases,finding possible targets for various skin diseases and developing gene therapy schemes in the future.In this review,we summarize the recent advances in the research of NF-kappa B signal transduction pathway and A20,and summarize their relationship with various skin diseases.