经外周中心静脉置管与植入式静脉输液港辅助化疗在结直肠癌肝转移患者中的应用效果

Application effect of peripherally inserted central venous catheter and implantable venous access port adjuvant chemotherapy for colorectal cancer with liver metastases

目的探究经外周中心静脉置管(PICC)与植入式静脉输液港(IVAP)辅助化疗在结直肠癌(CRC)肝转移患者中的应用效果。方法选择2016年1月至2018年1月我院收治的可转化治疗的CRC肝转移患者268例,随机分为PICC组和IVAP组,各134例。随访1年后,对比两组患者导管相关及非导管相关并发症的发生情况及生活质量。结果 IVAP组的导管平均留置时间为(335.7±21.8)d,明显长于PICC组的(246.9±32.5)d,差异有统计学意义(P<0.05)。IVAP组导管相关及非导管相关并发症总发生率均明显低于PICC组,差异有统计学意义(P<0.05)。IVAP组患者生活质量评分高(120～170分)的比例明显高于PICC组,差异有统计学意义(P<0.05)。结论 IVAP可作为可转化治疗的CRC肝转移患者反复多次化疗过程中的一种长期留置输液途径,此方法方便且安全,值得临床推广应用。

Objective To explore the application effect of peripherally inserted central venous catheter(PICC)and implantable venous access port(IVAP)adjuvant chemotherapy for colorectal cancer(CRC)with liver metastases.Methods A total of268patients with CRC with liver metastases treated with conversion therapy from January2016to January2018were enrolled and randomly divided into PICC group and IVAP group,with134cases in each group.After1year of follow-up,the incidences of catheter-related and non-catheter-related complications and quality of life were compared between the two groups.Results The mean catheter indwelling time in the IVAP group was(335.7±21.8)d,which was significantly longer than(246.9±32.5)d in the PICC group,the difference was statistically significant(P<0.05).The total incidences of catheter-related and non-catheter-related complications in the IVAP group were significantly lower than those in the PICC group,the differences were statistically significant(P<0.05).The rate of high quality of life(120-170points)in the IVAP group was significantly higher than that in the PICC group,the difference was statistically significant(P<0.05).Conclusion IVAP can be used as a long-term indwelling infusion route during repeated chemotherapy in CRC with liver metastasis patients with transformable therapy.This method is convenient and safe,which is worthy of clinical popularization and application.