全身静脉化疗与子宫动脉灌注化疗对中晚期宫颈癌的治疗效果

Therapeutic effect of intravenous systemic chemotherapy and uterine arterial infusion chemotherapy on medium and advanced cervical cancer

目的比较全身静脉化疗(ISC)与子宫动脉灌注化疗(AIC)对中晚期宫颈癌的治疗效果。方法选取我院收治的120例中晚期宫颈癌行新辅助化疗的患者为研究对象,按照不同化疗方式分为静脉组(60例,ISC)与动脉组(60例,AIC)。比较两组患者的治疗效果、肿瘤相关指标水平、骨髓和肝肾功能及术后效果。结果治疗后,动脉组患者的治疗总有效率显著高于静脉组(P<0.05);治疗后,两组患者的血清CEA、CA125、SCC-Ag、TK1水平均降低,动脉组SCC-Ag、TK1水平均低于静脉组(P<0.05);治疗后,两组患者的WBC、PLT均降低,ALT/AST、Scr水平均升高,但动脉组均优于静脉组(P<0.05)。动脉组术后淋巴转移率、宫旁浸润率均低于静脉组(P<0.05)。结论中晚期宫颈癌患者术前采用子宫动脉灌注行新辅助化疗的疗效更显著,对骨髓、肝肾的毒副作用小,术后效果好,值得推广与应用。

Objective To compare the therapeutic effects of intravenous systemic chemotherapy(ISC)and uterine arterial infusion chemotherapy(AIC)on medium and advanced cervical cancer.Methods A total of120patients with medium and advanced cervical cancer received neoadjuvant chemotherapy admitted to our hospital were selected as the study subjects and divided into intravenous group(60cases,ISC)and arterial group(60cases,AIC)according to the different chemotherapy methods.The therapeutic effects,levels of tumor correlation indexes,bone marrow,liver and kidney function and postoperative effects of the two groups were analyzed and compared.Results After treatment,the total effective rate of treatment in the arterial group was significantly higher than that in the intravenous group(P<0.05).After treatment,levels of serum CEA,CA125,SCC-Ag and TK1in the two groups decreased,and the levels of SCC-Ag and TK1in the arterial group were lower than those in the intravenous group(P<0.05).After treatment,the WBC and PLT decreased,and ALT/AST and levels of Scr elevated in both groups,but those in the arterial group were superior to the intravenous group(P<0.05).The rates of postoperative lymphatic metastasis and parametrial infiltration in the arterial group were lower than those in the intravenous group(P<0.05).Conclusion Neoadjuvant chemotherapy of uterine arterial infusion on patients with medium and advanced cervical cancer has more significant effect,it has little toxic and side effects on bone marrow,liver and kidney,and has good postoperative effect.It is worthy of promotion and application.