急性泌尿系统感染患者的致病菌分布特点与耐药性检测结果

Distribution characteristics and drug resistance detection results of pathogenic bacteria in patients with acute urinary system infection

目的分析急性泌尿系统感染患者致病菌的分布特点与耐药性检测结果。方法回顾性分析125例急性泌尿系统感染患者的临床资料,分析其致病菌的分布特点及耐药性检测结果。结果本组患者共分离出135株病原菌,其中革兰阴性菌、革兰阳性菌及真菌分别占57.78%、29.63%、12.59%,居于前3位的病原菌分别为大肠埃希菌、粪肠球菌和肺炎克雷伯菌,构成比分别为20.74%、14.81%、8.15%。大肠埃希菌对哌拉西林、头孢唑林、头孢呋辛、头孢曲松及左氧氟沙星的耐药性较高(>50%),粪肠球菌对哌拉西林、头孢噻肟、氨曲南的耐药性较高(>50%),肺炎克雷伯菌对厄他培南、亚胺培南和左氧氟沙星的耐药性较高(>50%)。结论急性泌尿系统感染患者的致病菌以革兰阴性菌为主,且对抗菌药物的耐药性严重,临床应加强病原菌的监测和药敏试验。

Objective To analyse the distribution characteristics and drug resistance detection results of pathogenic bacteria in patients with acute urinary tract infection.Methods The clinical data of125patients with acute urinary tract infection were reviewed,and the distribution characteristics of pathogenic bacteria and drug resistance test results were analyzed.Results A total of135pathogenic bacteria were isolated,and Gram-negative bacteria,Gram-positive bacteria and fungi accounted for57.78%,29.63%,12.59%,respectively.The pathogenic bacteria in the top3were Escherichia coli,Enterococcus faecalis and Klebsiella pneumoniae,the composition ratio was20.74%,14.81%,8.15%.Escherichia coli was highly resistant to piperacillin,cefazolin,cefuroxime,ceftriaxone and levofloxacin(>50%),Enterococcus faecalis was highly resistant to piperacillin,cefotaxime and aztreonam(>50%),Klebsiella pneumoniae was highly resistant to ertapenem,imipenem and levofloxacin(>50%).Conclusion The pathogenic bacteria of patients with acute urinary tract infection are mainly Gram-negative bacteria,and the resistance to antibiotics is serious.The monitoring and drug susceptibility test of pathogenic bacteria should be strengthened in clinic rational drug use.