原发性肝细胞癌的CT影像组学分析

CT radiomic features of primary hepatocellular carcinoma

目的:应用影像组学方法量化原发性肝细胞癌在CT增强扫描时"快进快出"的影像学表现。方法:在平扫期、动脉期、门脉期上勾画肿瘤靶区(GTV)和部分正常肝脏组织,提取所勾画靶区的特征值,量化GTV以及正常肝脏组织在不同时相上影像组学特征值的差异。结果:共提取55个特征,正常肝脏组织和GTV在平扫期与动脉期、平扫期与门脉期、动脉期与门脉期所提取的特征差异具有统计学意义的分别有7、8、22个和35、41、33个;GTV与正常肝脏组织在平扫期差异具有统计学意义的特征有49个,动脉期46个,门脉期38个;有6个特征与"快进快出"现象有关。结论:基于影像组学技术量化不同强化时机肝细胞癌和正常肝脏组织的特征,为追踪肝细胞癌肿瘤异质性及动态变化提供有效的手段。

Objective To apply radiomics for the quantitative analysis of the"fast-in,fast-out"of primary hepatocellular carcinoma(HCC)in enhanced CT scan.Methods Gross tumor volume(GTV)and partial normal liver tissues were selected as regions of interest(ROI)in different contrast-enhanced CT phases,such as plain scan phase,arterial phase and portal venous phase.After the features of target areas were extracted,the differences in radiomic features of GTV and normal liver tissue between different CT contrast-enhanced phases were quantified.Results A total of 55 radiomic features were extracted from each ROI.The number of the radiomic features with statistical significance in comparison of the normal liver tissue and GTV of plain scan phase versus arterial phase,plain scan phase versus portal venous phase,and arterial phase versus portal venous phase was 7,8,22,and 35,41,33,respectively.There were 49,46,38 features changed significantly between GTV and normal liver tissue in the plain scan phase,arterial phase and portal venous phase,respectively.And 6 radiomic features of GTV are related to the"fast-in,fast-out"phenomenon.Conclusion The radiomics which can be used to quantitative analyze the features of HCC and normal liver in contrast-enhanced CT phases provides an efficient method for tracking the HCC heterogeneity and the dynamic changes of the tumor.