消旋山莨菪碱片与布洛芬治疗原发性痛经的疗效对比研究

Comparative Study of Efficacy of Raceanisodamine Tablets and Ibuprofen in Treatment of Primary Dysmenorrhea

目的:比较消旋山莨菪碱片与布洛芬治疗原发性痛经的临床疗效。方法:回顾性选取2016年1月至2018年6月东莞市塘厦医院妇科门诊治疗的原发性痛经患者150例,依照不同给药方式分为观察组和对照组,每组75例。观察组患者应用消旋山莨菪碱片治疗,对照组患者应用布洛芬治疗,比较两组患者的药物控制成效、不良反应发生情况。结果:观察组患者药物控制总有效率为94.67%(71/75),明显高于对照组的85.33%(64/75),差异有统计学意义(P<0.05);观察组患者总不良反应发生率为5.33%(4/75),明显低于对照组的14.67%(11/75),差异有统计学意义(P<0.05)。结论:与布洛芬比较,消旋山莨菪碱片治疗原发性痛经更具优势,对布洛芬耐受性较差的患者可选用消旋山莨菪碱片替代治疗,可减少不良反应的发生。

OBJECTIVE:To compare the clinical efficacy of Raceanisodamine tablets and ibuprofen in treatment of primary dysmenorrhea.OBJECTIVE:150patients with primary dysmenorrhea admitted into gynecology department of Dongguan Tangxia Hospital from Jan.2016to Jun.2018were retrospectively extracted to be divided into observation group and control group via different administration route,with75cases in each.The observation group was given Raceanisodamine tablets,while the control group received ibuprofen.The drug control effectiveness,incidence of adverse drug reactions of two groups were compared.RESULTS:The total drug control effectiveness of observation group was94.67%(71/75),signidicantly higher than that of control group(85.33%,64/75),with statistically significant difference(P<0.05).The total incidence of adverse drug reactions in observation group was5.33%(4/75),significantly lower than that in control group(14.67%,11/75),with statistically significant difference(P<0.05).CONCLUSIONS:Compared with ibuprofen,Raceanisodamine tablets in treatment of primary dysmenorrhea have more advantages in treatment of primary dysmenorrhea.In patients with poor tolerance to ibuprofen,alternative treatment with Raceanisodamine tablets can be used to reduce the incidence of adverse drug reactions.