摘要
目的评估桥本甲状腺炎(HT)与甲状腺乳头状癌(PTC)患者的BRAF突变率和侵袭性。方法使用计算机检索中国期刊全文数据库、万方数据库、中文科技期刊数据库,以及PubMed等英文数据库,收集包含PTC,HT和BRAF突变等相关关系的中英文文献,应用RevMan5.3软件对数据进行meta分析。结果共纳入文献10篇,涉及PTC病例4 265例。meta分析结果显示:与PTC组相比,PTC合并HT组的BRAF突变率,甲状腺外侵犯率和淋巴结转移率显著降低(P<0.05);当BRAF突变存在时,PTC合并HT组的甲状腺外侵犯率仍然显著低于PTC组(P<0.05),但是两组的淋巴结转移率比较差异无统计学意义(P>0.05)。结论与不合并HT的PTC患者相比,合并HT的PTC患者表现出较低的BRAF突变率和侵袭性,即使是在BRAF阳性突变存在时,HT仍能在一定程度上阻碍PTC的进展和侵袭性。
Objective To evaluate the BRAF mutation rate and invasion in the patients with papillary thyroid carcinoma(PTC)and the patients with Hashimoto thyroiditis(HT).Methods The databases of CNKI,Wanfang,VIP and PubMed English databases were retrieved by computer for collecting the Chinese and English literatures containing PTC,HT and BRAF mutation.The meta analysis was performed by using RevMan 5.3 software.Results A total of 10 articles involving 4 265 PTC patients were included.The meta analysis results showed that compared with the PTC group,the BRAF mutation rate,invasion rate outside thyroid gland and lymph node metastasis rate in the PTC complicating HT group were significantly decreased(P<0.05);when BRAF mutation existed,the invasion rate outside thyroid gland in the PTC complicating HT group was significantly lower than that in the PTC group(P<0.05),but the lymph node metastasis rate had no statistical difference between the two groups(P>0.05).Conclusion Compared with the PTC patients without complicating HT,the patients with PTC complicating HT show lower BRAF mutation rate and low invasiveness,even the BRAF positive mutation exists,HT can hinder the progression and invasiveness of PTC to a certain extent.
作者
唐雯
尚恒
李彦国
庞雅贤
何雪娟
TANG Wen;SHANG Heng;LI Yanguo;PANG Yaxian;HE Xuejuan(Teaching and Researching Section of Preventive Medicine,Cangzhou Medical College,Cangzhou,Hebei 061000,China;Department of Endocrinology,Cangzhou Municipal People′s Hospital,Cangzhou,Hebei 061000,China)
出处
《重庆医学》
CAS
2018年第36期4614-4618,共5页
Chongqing medicine
基金
2015年度河北省科技计划资助项目(152777167)