常见金属离子对鲍曼不动杆菌生物活性的影响

Influence of common metal ions on biological activity of Acinetobacter baumannii

鲍曼不动杆菌是医院获得性感染的主要致病菌,临床上多重耐药鲍曼不动杆菌日趋增多,抗感染治疗面临困境,亟需寻找能有效抑制鲍曼不动杆菌的方法。金属离子是细菌维持生理进程和毒力活性所必需的,在抗生素出现之前,金属离子就被用于治疗细菌感染。本文通过阐述常见金属离子(铁、锌、锰、铜等)对鲍曼不动杆菌生物活性的影响,旨在使研究者充分认识金属离子的抑菌作用,为治疗鲍曼不动杆菌感染提供新思路和依据。

Acinetobacter baumannii is the main pathogenic bacteria of hospital acquired infection.Multiple drug resistant Acinetobacter baumannii is rapidly increasing in clinical practice,which leads to a difficulty of anti-infection treatment.It is an urgent need to find better ways to effectively inhibit Acinetobacter baumannii.Metal ions are necessary to sustain the physiological process and keep virulence active in bacteria.They have been used to deal with bacterial infections before the advent of antibiotics.In this review,we focused on the influence of metal ions(Fe,Zn,Mn,Cu,etc.)on the bioactivity of Acinetobacter baumannii.We aimed to make the researchers fully understand the bacteriostasis of metal ions and supply new ways for the treatment of Acinetobacter baumannii infection.