经肝动脉自体骨髓干细胞肝内移植治疗对失代偿期肝硬化临床效果、肝功能及凝血指标的影响

Effect of intrahepatic transplantation of hepatic artery autologous bone marrow stem cells influence on clinical outcome, liver function and coagulation parameters of decompensated liver cirrhosis

目的观察失代偿期肝硬化经肝动脉自体骨髓干细胞肝内移植治疗的临床效果及对肝功能、凝血指标的影响。方法选取2016年12月～2017年12月内蒙古医科大学附属医院外科收治的68例失代偿期肝硬化患者,均经肝动脉自体骨髓干细胞肝内移植治疗。观察其临床疗效、并发症,比较其治疗前后症状、肝功能、凝血指标、生活质量。结果 68例患者临床总有效率为92.65%,术后并发症发生率为8.82%,治疗后乏力、纳差、腹胀、黄疸、腹水的评分较治疗前低(P <0.05);治疗后肝功能指标(总胆红素、谷草转氨酶、谷丙转氨酶、白蛋白)较治疗前有所改善(P <0.05),治疗后躯体健康、心理健康、社会功能、物质生活评分及总分较治疗前有所提升(P <0.05)。结论失代偿期肝硬化患者经肝动脉自体骨髓干细胞肝内移植治疗的效果确切,症状显著缓解,肝功能得到改善,不影响凝血功能,患者生活质量提升,且安全有效。

Objective To observe the clinical effect of hepatic arterial autologous bone marrow stem cell intrahepatic transplantation for decompensated cirrhosis and its influence on liver function and coagulation indicators.Methods A total of68patients with decompensated liver cirrhosis admitted to Department of Surgery of the Affiliated Hospital of Inner Mongolia Medical University from December2016to December2017were selected and intrahepatic transplantation of hepatic artery autologous bone marrow stem cells was performed on all of the patients.The clinical efficacy and complications were observed.The symptoms,liver function,coagulation index and quality of life were compared before and after treatment.Results The total effective rate was68.6%in68patients,and the postoperative complication rate was8.82%.After treatment,the scores of fatigue,anorexia,abdominal distension,jaundice and ascites were lower than those before treatment(P<0.05).The liver function index(tatal bilirubin aspartate asninotransferose,alanine amin of ranferase,albwnin)after treatment were improved compared with those before treatment(P<0.05).The physical health,mental health,social function,material life score and total score after treatment were improved compared with those before treatment(P<0.05).Conclusion For patients with decompensated cirrhosis,intrahepatic transplantation of hepatic artery autologous bone marrow stem cells is effective,the symptoms are relieved,liver function is improved,coagulation function is not affected,and the quality of life of patients is improved,and it is safe and effective.