咪唑并杂环化合物的设计、合成及抗乳腺癌活性研究

Design,Synthesis and Anti Breast Cancer Activity of Imidazole Heterocyclic Compounds

研究了咪唑并杂环化合物的设计、合成及抗乳腺癌活性。以裸鼠作为实验对象,对咪唑并杂环化合物进行设计与合成实验,同时对其抗乳腺癌活性进行验证。结果表明,对其进行活性筛选之后发现,2a、4a、4b、4c的活性相对较好,其中2a具有最强活性,能够促进乳腺癌细胞凋亡;合成12个咪唑并杂环化合物,其中存在3个结构比较新颖的化合物,从中找到4个抗癌活性较好化合物。2a能够促进癌细胞凋亡,其在体内具有较高安全性,具备抗乳腺癌活性。

Objective To study the design,synthesis and anti breast cancer activity of imidazole heterocyclic compounds.Methods The design and synthesis of imidazolium heterocyclic compounds in nude mice were studied,and the anti-breast cancer activity of imidazolium heterocyclic compounds was verified.Results The activity of 2a,4a,4B and 4C was relatively good after screening.Among them,2A had the strongest activity and could promote the apoptosis of breast cancer cells.Conclusion 12 imidazole heterocyclic compounds are synthesized,of which 3 are relatively novel compounds.4 compounds with good anticancer activity were found.2A can promote apoptosis of cancer cells.It has high safety in vivo and has anti breast cancer activity.