卵巢功能去势在绝经前转移性乳腺癌患者中的应用

Clinical observation of ovarian function castration for premenopausal metastatic breast cancer

目的观察卵巢功能去势在绝经前转移性乳腺癌患者中的临床应用。方法选取118例确诊为绝经前转移性乳腺癌的患者作为研究对象,对照组研究对象接受常规化疗,观察组研究对象在对照组基础上给予戈舍瑞林,采用电化学发光法检测雌二醇及卵泡刺激素水平。采用GE-Vivid 7型彩超诊断仪检测卵巢间质动脉的峰值流速及阻力指数。结果观察组总有效率(44.83%)较对照组总有效率(32.76%)高。治疗6个月后两组研究对象FSH及E2水平较治疗前均有所下降,观察组FSH及E2水平均较对照组高;治疗12个月后观察组研究对象FSH及E2水平较治疗6个月时有所升高,而对照组研究对象FSH及E2水平较治疗6个月时无明显改变。治疗6个月及12个月后两组研究对象PSV较治疗前均有所下降,观察组PSV均较对照组低;治疗6个月及12个月后两组研究对象RI较治疗前均有所上升,观察组RI均较对照组高。结论卵巢功能去势在绝经前转移性乳腺癌患者中应用不仅具有较好的疗效,且具有保护卵巢功能的作用。

Objective To observe the clinical application of ovarian function castration for premenopausal metastatic breast cancer. Methods 118 confirmed cases of premenopausal metastatic breast cancer in our hospital were enrolled. Convention hemotherapieswere given to the control group and goserelinwere given to the observation group. The level of estradiol and follicle stimulating hormone was measured by eletrochemiluminescence method. The peak systolic velocity and resistance index was measured by type GE-Vivid 7 color ultrasonography.Results The total effective rate in the observation group(44.83%)was higher than that in control group( 32.76%).The levels of FSH and E2 in 6 months after therapy in observation were higher than that of control group. The levels of FSH and E2 increased in 12 months after therapy than in 6 months after therapy in the observation group, but the levels of FSH and E2 had no obvious change in 12 months after therapy than in 6 months after therapy in control group. PSV decreased in 6 months after therapy and 12 months after therapy, the PSV, PSV in observation were lower than that of control group. RI increased in 6 months after therapy and 12 months after therapy, the RIin observation group were higher than that of control group. Conclusions Ovarian function castration is not only effective for premenopausal metastatic breast cancer, but also protect the ovarian function.