同型半胱氨酸和叶酸浓度与陕西汉中地区妊娠期糖尿病关联研究

Plasma homocysteine and folic acid associated with gestational diabetes mellitus study in Hanzhong region Shaan′xi province

目的探讨血浆同型半胱氨酸、叶酸浓度与妊娠期糖尿病的关系。方法选取314例妊娠期糖尿病患者,同一地区健康孕妇347例作为对照组。空腹采集乙二胺四乙酸钠盐抗凝静脉全血5mL,血浆同型半胱氨酸浓度检测采用循环酶法,血浆叶酸浓度检测采用化学发光法检测,统计分析采用SPSS17.0分析软件处理,定量资料比较采用t检验。数据相关性分析使用Pearson相关分析。以P<0.05为差异有统计学意义判断标准。结果妊娠期糖尿病组血浆同型半胱氨酸水平明显高于对照组,差异有统计学意义(P<0.05);妊娠期糖尿病组血浆叶酸水平明显低于对照组,差异有统计学意义(P<0.05);妊娠期糖尿病组相关分析发现,血浆同型半胱氨酸和叶酸水平呈负相关分布(r=-0.431,P<0.05)。结论血浆同型半胱氨酸和叶酸水平可能与妊娠期糖尿病密切相关,并且同型半胱氨酸水平和叶酸水平呈负相关关系。

Objective The aim of the study is to compare plasma homocysteine,folic acid level association with gestational diabetes.Methods 314 women with GDM and 347 normal controls in the same area were recruited in this study.Venous blood was collected on an empty stomach EDTA anticoagulant 5 ml,Plasma homocysteine detection using recycling enzymatic method,plasma folic acid detection using the electrochemical luminescence method.Statistical analysis using IBM SPSS 17 software.Results The GDM group in plasma that Hcy level is significantly higher than the control group(P<0.05);The GDM group in plasma that FA level is significantly lower than the control group(P<0.05);GDM group of related analysis found that plasma Hcy and FA levels negatively correlated distribution(r=-0.431,P<.05).Conclusion Plasma homocysteine and folic acid levels may be closely associated with gestational diabetes,and homocysteine level are negatively correlated distribution with folic acid level.