11452例女性泌尿生殖道分泌物支原体培养及药敏结果分析

Mycoplasma culture and drug sensitivity analysis of 11452 female urogenital tract secretions

目的观察女性泌尿生殖道支原体感染情况并分析其耐药性。方法采用上海奥普生物医药有限公司生产提供的泌尿生殖道病原性支原体药敏定量培养板(MycoView)检测,同时测定支原体对7种抗菌药物的耐药性,回顾性分析2015年1月至2016年12月到上海市嘉定区妇幼保健医院进行支原体培养及药敏试验的11452例女性患者样本的临床特点。结果11452份泌尿生殖道分泌物标本中,有4933例检出支原体,感染率为43.07%,其中Uu占所有感染病例的78.49%,Uu+Mh占18.37%,Mh占3.14%。支原体对强力霉素、交沙霉素及米诺环素有较高的敏感性。支原体感染在各年龄组分布差异有统计学意义(P<0.05),其中以≤25岁感染率最高,为46.34%。结论本地区支原体感染以Uu为主,在不同年龄段感染率有差异。Uu、Mh、Uu+Mh感染时耐药率不同,建议临床医生应考虑本地区耐药株的流行情况,根据药敏实验结果合理用药。

Objective To observe the mycoplasma infection in female genitourinary tract and to analyze its drug resistance.Methods A retrospective analysis of 11452 cases from January 2015 to December 2016 in Jiading maternity and infant health hospital was made to mycoplasma culture and drug susceptibility test.Results In the 11452 cases,the mycoplasma infection were 4933 cases,with the infection rate of 43.07%,including Uu accounted for 78.49%of all cases of infection,Uu+Mh(18.37%),Mh(3.14%).Mycoplasma had higher sensitivity to josamycin,doxycycline and minocycline.The detection rate ofmycoplasma in different age groups was significant(P<0.05),of which 25 or less infection rate was the highest,at 46.34%.Conclusion Mycoplasma infection was given priority to Uu in this region,there were differences in infection rates in different ages.Since Uu,Mh and Uu+Mh infection rate were different,we suggested that clinical doctors should consider the prevalence of drug resistant strains in this region,using drug rationally according to the results of drug susceptibility test.