香菇多糖联合胸腺五肽辅助化疗对舌鳞状细胞癌患者免疫、氧化应激、基质金属蛋白酶及相关因子水平的影响

Effects of lentinan and thymopentin combined with adjuvant chemotherapy on immunity,oxidative stress,matrix metalloproteinases and related factors in patients with tongue squamous cell carcinoma

目的:探究香菇多糖联合胸腺五肽辅助化疗对舌鳞状细胞癌患者免疫、氧化应激、基质金属蛋白酶及相关因子水平的影响。方法:回顾性分析我院口腔科收治的78例舌鳞状细胞癌患者,根据术后化疗方案分为对照组(n=42)与观察组(n=36),对照组予以PF化疗方案(顺铂+复方氟尿嘧啶注射液),在此基础上观察组予以香菇多糖及胸腺五肽注射液联合治疗。分别对两组患者治疗前后免疫指标、氧化应激、基质金属蛋白酶、细胞周期蛋白D1(CyclinD1)及B淋巴细胞瘤-2(BCL-2)进行检测分析。结果:治疗后,对照组免疫球蛋白水平与治疗前相比,无统计学意义(P>0.05),观察组IgA、IgG与IgM水平较治疗前显著升高(P<0.05),且观察组IgA、IgG与IgM水平显著高于对照组(P<0.05);对照组SOD水平显著低于治疗前(P<0.05),MDA水平显著高于治疗前(P<0.05);而观察组则相反,且其SOD水平显著高于对照组(P<0.05),MDA水平显著低于对照组(P<0.05);两组MMP-2与MMP-9水平较治疗前显著降低(P<0.05),且观察组MMP-2与MMP-9水平显著低于对照组(P<0.05);两组CyclinD1与BCL-2水平较治疗前显著降低(P<0.05),且观察组CyclinD1与BCL-2水平显著低于对照组(P<0.05)。结论香菇多糖及胸腺五肽辅助PF化疗方案,可增强舌鳞状细胞癌根治术后患者免疫功能,改善氧化应激反应,抑制肿瘤细胞增生及转移,具有临床推广意义。

Objective:To investigate the effects of lentinan and thymopentin combined with adjuvant chemotherapy on immunity,oxidative stress,matrix metalloproteinases and related factors in patients with tongue squamous cell carcinoma.Methods;Retrospective analysis of 78 patients with tongue squamous cell carcinoma admitted to our hospital from February 2013 to November 2017,according to the postoperative chemotherapy scheme,the patients were divided into control group(n=42)and observation group(n=36).The patients in control group were given PF chemotherapy scheme(cisplatin+compound fluorouracil injection),on this basis,the patients in observation group were given lentinan and thymopentin injection combined treatment.The immune index,oxidative stress,matrix metalloproteinase,cyclin D1(CyclinD1)and B lymphocyte tumor-2(BCL-2)were detected and analyzed before and after treatment.Results:After treatment,the immunoglobulin level in the control group was not statistically significant compared with that before treatment(P>0.05);the levels of IgA,IgG and IgM in the observation group were significantly higher than those before treatment(P<0.05),and the levels of IgA,IgG and IgM in the observation group were significantly higher than those in the control group(P<0.05);the level of SOD in control group was significantly lower than that before treatment(P<0.05),and the level of MDA was significantly higher than that before treatment(P<0.05);the observation group was the opposite,and its SOD level was significantly higher than that of the control group(P<0.05),and the MDA level was significantly lower than the control group(P<0.05);the levels of MMP-2 and MMP-9 in the two groups were significantly lower than those before treatment(P<0.05),and the levels of MMP-2 and MMP-9 in the observation group were significantly lower than those in the control group(P<0.05);the levels of CyclinD1 and BCL-2 in the two groups were significantly lower than those before treatment(P<0.05),and the levels of CyclinD1 and BCL-2 in the observation group were significantly lower than those in the control group(P<0.05).Conclusions:Lentinan and thymopentin assisted PF chemotherapy regimen can enhance the immune function of patients with tongue squamous cell carcinoma after radical surgery,improve oxidative stress response,inhibit tumor cell proliferation and metastasis.It has the significance of clinical popularization.