miRNAs在肝细胞癌中的功能及应用前景

The function and application prospect of miRNAs in hepatocellular carcinoma

肝细胞癌(HCC)是最常见的原发性肝脏恶性肿瘤,是全世界癌症死亡的主要原因之一,其显著特征是预后不良。因此,越来越多的研究集中于为HCC诊断和预后寻找新的分子标志物。microRNAs(mi RNAs)是小的非编码RNA。表达失调的mi RNAs其本身充当癌基因或肿瘤抑制基因,参与癌症的发生发展。新近研究发现,mi RNAs的异常表达参与了HCC的许多生物过程,本文主要总结近年关于mi RNAs在HCC肿瘤发生发展中作用的研究,为mi RNAs用于HCC诊断、预后或作为治疗靶点提供理论依据。

Hepatocellular carcinoma(HCC)is the most common primary malignant tumor of the liver and is one of the leading causes of cancer deaths in the world,it is characterized by a poor prognosis.More and more researches have focused on finding new molecular markers for HCC diagnosis and prognosis.microRNAs(miRNAs)is a sort of small and non-coding RNA.Deregulated miRNAs themselves act as oncogenes or tumor suppressor genes and are involved in the development and progression of cancer.Recent studies have found that the abnormal expression of many miRNAs is involved in many biological processes of HCC.This paper summarizes the studies on the role of miRNAs in the development and progression of HCC tumors in recent years,and provides a theoretical basis for the application of miRNAs in HCC diagnosis,prognosis or as a therapeutic target.