老年肺炎患者血清降钙素原、超敏C反应蛋白及D-二聚体水平的表达及意义

Expression of Serum Procalcitonin,Hypersensitive C-reactive Protein and D-dimer in Senile Pneumonia

目的:探讨血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)及D-二聚体(D-Dimer)水平在老年肺炎中的表达及意义。方法:47例老年肺炎患者作为观察组,再根据CURB-65评分分为低危组(n=20)、中危组(n=15)及高危组(n=12),选取同期健康体检老年人20例作为对照组;分别于入院或体检时检测血清PCT、hsCRP及D-Dimer水平,分析不同程度老年肺炎患者病情与PCT、hs-CRP及D-Dimer的关系。结果:与对照组比较,观察组老年肺炎患者血清PCT、hs-CRP及D-Dimer水平显著升高,差异有统计学意义(P <0. 05); 3组老年肺炎患者血清PCT、hs-CRP及D-Dimer水平比较,高危组>中危组>低危组,差异有统计学意义(P <0. 05)。结论:血清PCT、hs-CRP及D-Dimer水平检测能用于老年肺炎病情危重程度的判断。

Objective:To investigate the expression and significance of serum procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP)and D-dimer in senile pneumonia.Methods:47elderly patients with pneumonia were divided into three groups according to CURB-65score:low risk group(n=20),moderate risk group(n=15)and high risk group(n=12).20healthy aged persons were selected as control group.The serum levels of PCT,hs-CRP and D-Dimer were measured at admission or physical examination,and the relationship between PCT,hs-CRP and D-Dimer in elderly patients with pneumonia of different degrees was analyzed.Results:Compared with the control group,the serum levels of PCT,hs-CRP and D-Dimer in the elderly patients with pneumonia in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of serum PCT,hs-CRP and D-Dimer levels among three groups of elderly patients with pneumonia were compared:high risk group>medium risk group>low risk group,and the difference was statistically significant(P<0.05).Conclusion:Serum PCT,hs-CRP and D-Dimer levels can be used to judge the severity of pneumonia in the elderly.