万古霉素持续静脉给药治疗新生儿败血症的临床观察

The clinical study on therapeutic effects of vancomycin by continuous intravenous administration in treating septicemia of newborn

目的观察万古霉素的持续静脉给药在新生儿败血症治疗中的临床效果和对炎性因子、肝肾功能影响。方法 96例新生儿败血症随机分为对照组和实验组,每组48例。对照组予万古霉素的传统给药方式,实验组为持续静脉给药方式。比较两种给药方案对败血症新生儿疗效及治疗前后炎症因子、肝肾功能指标变化的差异。结果实验组的初始有效率显著高于对照组(vs72.9%52.1%,P<0.05),炎性指标血沉(ESR)、降钙素原(PCR)、C反应蛋白(CRP)的下降幅度明显大于对照组(均P<0.05)。两种给药方式对患儿肝肾功能的影响差异无统计学意义(P>0.05)。结论万古霉素持续静脉给药治疗新生儿败血症,能够提高初始有效率,降低炎性指标的水平。

Objective To evaluate therapeutic effects and influence of inflammatory indicators and hepatic and renal function of vancomycin by continuous intravenous administration in treating septicemia of newborns.Methods According to different administration methods,96 neonates with sepsis were divided into control group and experimental group,with 48 cases in each group.The control group was given traditional mode of administration of vancomycin while the experimental group was administered by continuous intravenous administration.The effects of two drug regimens on neonatal sepsis and the changes of inflammation index and liver and kidney function indexes before and after treatment were analyzed.Results Compared with traditional mode of administration,continuous intravenous administration increased the initial effective rate of neonatal treatment of sepsis(P<0.05);effectively reduced the level of inflammatory index(ESR,PCT)in children(both P<0.05).There was no significant difference in the effects of the two modes of administration on liver and kidney function(P>0.05).Conclusion Continuous intravenous administration of vancomycin for neonates with sepsis can increase initial efficiency and reduce the level of inflammatory markers.